5 prime ureB sRNA
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In molecular biology, 5' ureB sRNA is a small RNA. It is located at the 5' end of the ureB gene in the urease gene cluster and is antisense to ureB. Its expression is regulated by the arsS/arsR two-component regulatory system, arsS downregulates 5' ureB sRNA expression under acidic conditions leading to an increase in ureB expression. 5' ureB sRNA suppresses transcription of ureA and ureB by base-pairing with ureAB mRNA resulting in premature termination of the transcript to the 5' of ureB.[1][2]
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References[edit]
- ^ Wen, Y; Feng, J; Scott, DR; Marcus, EA; Sachs, G (January 2011). "A cis-encoded antisense small RNA regulated by the HP0165-HP0166 two-component system controls expression of ureB in Helicobacter pylori". Journal of Bacteriology. 193 (1): 40–51. doi:10.1128/jb.00800-10. PMC 3019956. PMID 20971914.
- ^ Wen, Y; Feng, J; Sachs, G (February 2013). "Helicobacter pylori 5'ureB-sRNA, a cis-encoded antisense small RNA, negatively regulates ureAB expression by transcription termination". Journal of Bacteriology. 195 (3): 444–452. doi:10.1128/jb.01022-12. PMC 3554021. PMID 23104809.