File:CRISPR Cas system.png
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Summary
| Description |
English: CRISPR Cas12a (AsCpf1) system has been successfully harnessed for mammalian genome editing. AsCpf1 nuclease uses the single guide RNA to find a specific target sequence to introduce double-strand break. Then, the cell introduces a mutation at the site of the break through the repair mechanisms of damaged DNA.
Русский: CRISPR Cas12a (AsCpf1) система успешно используется для редактирования генома млекопитающих. Нуклеаза AsCpf1 с помощью направляющей РНК находит точное место в геноме, чтобы внести двухцепочечный разрыв. Затем клетка вносит мутацию в месте внесенного разрыва с помощью механизмов репарации поврежденной ДНК. English: Cas12a in complex with crRNA and target DNA. Three-dimensional structure of Cas12(AsCpf1) ID 5B43 from the Protein Data Bank (PDB) database. Structural image was prepared with the PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC and Adobe Illustrator. |
| Date | |
| Source | Own work |
| Author | Elena I Leonova |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 21:13, 28 March 2020 | | 2,920 × 1,508 (1.47 MB) | Elena I Leonova | Uploaded own work with UploadWizard |
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