File:Pantothenic acid biosynthesis.svg

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Summary

Description
English: Biosynthesis of pantothenic acid (vitamin B5). B5 is shown as pantothenate (anion).1

This route is followed by most bacteria like Escherichia coli, Salmonella typhimurium and Corynebacterium glutamicum. Importance of the routes may vary. E.g.: in S. typhimurium most of the α-ketoisovalerate is provided by dihydroxy-acid dehydratase.1

Most plants and archaea follow a very similar route, and make B5 by joining pantoate and β-alanine.2

α-ketoisovalerate can revert back to valine and vice versa.1

All of the BCAT and valine-pyruvate transaminase substrates are not shown.

EC numbers are:

  • 4.2.1.9 dihydroxy-acid dehydratase
  • 2.6.1.42 BCAT (Branched-chain-amino-acid transaminase)
  • 2.6.1.66 valine—pyruvate transaminase
  • 2.1.2.11 ketopantoate hydroxymethyltransferase
  • 1.1.1.169 ketopantoate reductase
  • 1.1.1.86 ketol-acid reductoisomerase
  • 4.1.1.11 aspartate 1-decarboxylase
  • 6.3.2.1 pantothenate synthase

Sources:

  • 1. Leonardi, R; Jackowski, S (2007). "Biosynthesis of Pantothenic Acid and Coenzyme A". EcoSal Plus. 2 (2). doi:10.1128/ecosalplus.3.6.3.4. ISSN 2324-6200.
  • 2. Handbook of vitamins. Zempleni, J et al (4th ed.). Taylor & Francis. 2007. pp. 290–291. ISBN 9780849340222
Date
Source Own work
Author Keministi

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