Hepatoma-derived growth factor

HDGF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RI0, 2NLU
Identifiers
Aliases	HDGF, HMG1L2, hepatoma-derived growth factor, heparin binding growth factor
External IDs	OMIM: 600339 MGI: 1194494 HomoloGene: 3306 GeneCards: HDGF
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1 Start 156,742,109 bp End 156,766,925 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 38.78 cM Start 87,813,628 bp End 87,823,439 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right uterine tube rectum gastrocnemius muscle skin of abdomen monocyte pancreatic ductal cell right lobe of liver gallbladder duodenum Top expressed in otic placode saccule lip yolk sac morula corneal stroma extensor digitorum longus muscle lens esophagus plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA binding transcription corepressor binding transcription corepressor activity growth factor activity heparin binding RNA binding Cellular component cytoplasm transcription repressor complex nucleus nucleoplasm extracellular space extracellular matrix extracellular region collagen-containing extracellular matrix Biological process IRE1-mediated unfolded protein response cell population proliferation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated signal transduction cellular process regulation of signaling receptor activity cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3068 15191 Ensembl ENSG00000143321 ENSMUSG00000004897 UniProt P51858 P51859 RefSeq (mRNA) NM_001126050 NM_001126051 NM_004494 NM_001319186 NM_001319187 NM_001319188 NM_008231 NM_001331051 NM_001331052 RefSeq (protein) NP_001119522 NP_001119523 NP_001306115 NP_001306116 NP_001306117 NP_004485 NP_001317980 NP_001317981 NP_032257 Location (UCSC) Chr 1: 156.74 – 156.77 Mb Chr 3: 87.81 – 87.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Hepatoma-derived growth factor (HDGF) also known as high mobility group protein 1-like 2 (HMG-1L2) is a protein that in humans is encoded by the HDGF gene.

Further reading

• Everett AD, Bushweller J (2003). "Hepatoma derived growth factor is a nuclear targeted mitogen". Current Drug Targets. 4 (5): 367–71. doi:10.2174/1389450033490975. PMID 12816346.
• Nakamura H, Izumoto Y, Kambe H, et al. (1994). "Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein". J. Biol. Chem. 269 (40): 25143–9. doi:10.1016/S0021-9258(17)31509-0. PMID 7929202.
• Kishima Y, Yamamoto H, Izumoto Y, et al. (2002). "Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals". J. Biol. Chem. 277 (12): 10315–22. doi:10.1074/jbc.M111122200. PMID 11751870.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mori M, Morishita H, Nakamura H, et al. (2004). "Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth". Am. J. Respir. Cell Mol. Biol. 30 (4): 459–69. doi:10.1165/rcmb.2003-0013OC. PMID 12972397.
• Yoshida K, Nakamura H, Okuda Y, et al. (2004). "Expression of hepatoma-derived growth factor in hepatocarcinogenesis". J. Gastroenterol. Hepatol. 18 (11): 1293–301. doi:10.1046/j.1440-1746.2003.03191.x. PMID 14535987. S2CID 24881855.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
• Everett AD, Narron JV, Stoops T, et al. (2004). "Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor". Am. J. Physiol. Lung Cell Mol. Physiol. 286 (6): L1194–201. doi:10.1152/ajplung.00427.2003. PMID 14751852. S2CID 17651256.
• Sue SC, Chen JY, Huang TH (2004). "Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor". J. Biomol. NMR. 29 (1): 95–6. doi:10.1023/B:JNMR.0000019467.57276.05. PMID 15017145. S2CID 84545598.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shen XY, Zacal N, Singh G, Rainbow AJ (2005). "Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells". Photochem. Photobiol. 81 (2): 306–13. doi:10.1562/2004-07-22-RA-242. PMID 15560738.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Iwasaki T, Nakagawa K, Nakamura H, et al. (2005). "Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer". Oncol. Rep. 13 (6): 1075–80. doi:10.3892/or.13.6.1075. PMID 15870924.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684. S2CID 10789246.
• Clermont F, Gonzalez NS, Communi D, Franken S, Dumont JE, Robaye B (2008). "HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase-dependent way". J Cell Biochem. 104 (4): 1161–1171. doi:10.1002/jcb.21788. PMID 18465786. S2CID 8154321.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatoma-derived growth factor