Hydrocortisone aceponate

Hydrocortisone aceponate
Clinical data
Trade names	Cortavance, others
AHFS/Drugs.com	Monograph
Routes of; administration	Topical
Drug class	Corticosteroid
ATC code	D07AC16 (WHO) QD07AC16 (WHO);
Legal status
Legal status	EU: Rx-only;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	6-8 hours
Identifiers
	IUPAC name (11β)-21-(acetyloxy)-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate;
CAS Number	74050-20-7 ;
PubChem CID	68921;
DrugBank	DB14538 ;
ChemSpider	62148 ;
UNII	2340UP1L2G;
KEGG	D06876 ;
ChEBI	CHEBI:135746;
ChEMBL	ChEMBL2106309 ;
ECHA InfoCard	100.184.885
Chemical and physical data
Formula	C26H36O7
Molar mass	460.567 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)C;
	InChI InChI=1S/C26H36O7/c1-5-22(31)33-26(21(30)14-32-15(2)27)11-9-19-18-7-6-16-12-17(28)8-10-24(16,3)23(18)20(29)13-25(19,26)4/h12,18-20,23,29H,5-11,13-14H2,1-4H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1 ; Key:MFBMYAOAMQLLPK-FZNHGJLXSA-N ;
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Hydrocortisone aceponate is a veterinary corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions).^[4] It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid.

Medical Uses[edit]

Hydrocortisone aceponate is typically used for skin conditions in veterinary practices for dogs. In this instance, it can be used on acute otitis externa,^[1] a bacterial infection causing inflammation of the ear canal, as well as a treatment for itchy skin caused by allergies.^[2] Additionally, hydrocortisone aceponate can be used to treat hormonal disorders and immune and allergic disorders.^[5]^{[unreliable medical source?]} The main use for hydrocortisone aceponate is for atopic skin conditions and acute ear infections. It is shown to help with skin lesions and inflammation that respond to corticosteroids but may have been resistant to other treatments. It has been approved for veterinary use in the European Union.^{[citation needed]}

Cortavance[edit]

Cortavance is the brand name for a veterinary drug used to treat inflamed, itchy skin, typically caused by allergies. Additionally, a small study showed that the drug could be used to treat atopic dermatitis, with the results showing improvements in lesions and dryness. The only active ingredient in Cortavance is hydrocortisone aceponate, which acts to reduce inflammation. Since this is the only active ingredient, Cortavance can be used to study the pharmacological effects and benefits of hydrocortisone aceponate.^[1]

Easotic[edit]

Easotic is the brand name for a veterinary drug used to treat acute ear infections in dogs. The drug is composed of three active substances: hydrocortisone aceponate, miconazole nitrate and gentamicin. These are used in conjunction with hydrocortisone aceponate acts as an anti-inflammatory agent, miconazole nitrate has antifungal properties, and gentamicin is an antibiotic. The drug is used through ear drops and works to kill the foreign agent, prevent further spread, and mitigate symptoms.^[1]

Adverse effects[edit]

Side effects include:^[1]^[2]

Inhibition of bone formation
Suppression of calcium absorption
Delayed wound healing
Redness on skin

Chemistry[edit]

Hydrocortisone aceponate is a steroid which takes the form of a diester. Because of this special formation, it is effective at low doses and can be used to treat skin conditions. The diester increases transmission of the medicine^[2] through the skin and also increases the time that it remains in the affected area. Diesters have been proven to respond quicker and more effectively than non-steroid-based anti-inflammatory creams.^[6]

References[edit]

^ ^a ^b ^c ^d ^e "Easotic EPAR". European Medicines Agency (EMA). 24 February 2021.
^ ^a ^b ^c ^d "Cortavance EPAR". European Medicines Agency (EMA). 24 September 2021.
^ "Cortaderm EPAR". European Medicines Agency (EMA). 17 June 2022. Retrieved 9 February 2024.
^ Mukhopadhyay AK, Baghel V (2010). "A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients". Indian Journal of Dermatology, Venereology and Leprology. 76 (5): 591. doi:10.4103/0378-6323.69093. PMID 20827017.
^ "Hydrocortisone aceponate". DrugBank. Retrieved 2021-11-29.
^ Takahashi K, Sakano H, Numata N, Kuroda S, Mizuno N (November 2002). "Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin". Drug Development and Industrial Pharmacy. 28 (10): 1285–1294. doi:10.1081/ddc-120015362. PMID 12476874. S2CID 26471775.

External links[edit]

Cortisol Blocking

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[Easotic_EPAR-1] "Easotic EPAR". European Medicines Agency (EMA). 24 February 2021.

[Cortavance_EPAR-2] "Cortavance EPAR". European Medicines Agency (EMA). 24 September 2021.

[3] "Cortaderm EPAR". European Medicines Agency (EMA). 17 June 2022. Retrieved 9 February 2024.

[4] Mukhopadhyay AK, Baghel V (2010). "A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients". Indian Journal of Dermatology, Venereology and Leprology. 76 (5): 591. doi:10.4103/0378-6323.69093. PMID 20827017.

[DrugBank-5] "Hydrocortisone aceponate". DrugBank. Retrieved 2021-11-29.

[6] Takahashi K, Sakano H, Numata N, Kuroda S, Mizuno N (November 2002). "Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin". Drug Development and Industrial Pharmacy. 28 (10): 1285–1294. doi:10.1081/ddc-120015362. PMID 12476874. S2CID 26471775.

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