DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11gene.
DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40.[5]
The WDR23 locus is highly conserved from C. elegans to humans.[6]
DCAF11/WDR23 is the E3 ligase that specifically targets proteins for degradation via ubiquitination.[7][8][9]
WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.[10]
^Tang L, Choe KP (July 2015). "Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways". Mechanisms of Ageing and Development. 149: 88–98. doi:10.1016/j.mad.2015.06.001. PMID26056713. S2CID24399248.
Siswanto FM, Oguro A, Arase S, Imaoka S (October 2020). "WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes". Drug Metabolism and Pharmacokinetics. 35 (5): 441–455. doi:10.1016/j.dmpk.2020.06.007. PMID32839090. S2CID221307354.
Siswanto FM, Sakuma R, Oguro A, Imaoka S (August 2022). "Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 77 (8): 1503–1516. doi:10.1093/gerona/glac062. PMID35279029.