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2022–2023 mpox outbreak in Switzerland

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2022–2023 mpox outbreak in Switzerland
DiseaseMpox
Virus strainMonkeypox virus (West African clade)
LocationSwitzerland
Index caseBern, Switzerland
Arrival date21 May 2022
(2 years, 5 months, 1 week and 1 day ago)
DateAs of 22 August 2022
Confirmed cases416
Suspected cases‡0
Deaths
0
‡Suspected cases have not been confirmed by laboratory tests as being due to this strain, although some other strains may have been ruled out.

The 2022–2023 mpox outbreak in Switzerland is a part of the outbreak of human mpox caused by the West African clade of the monkeypox virus. The outbreak started in Switzerland on 19 May 2022,[1] with the country since then becoming one of the most affected in Europe.

Background

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These paragraphs are an excerpt from Mpox and 2022–2023 mpox outbreak.

Mpox (/ˈɛmpɒks/, EM-poks; formerly known as monkeypox)[2] is an infectious viral disease that can occur in humans and other animals. Symptoms include a rash that forms blisters and then crusts over, fever, and swollen lymph nodes. The illness is usually mild, and most infected individuals recover within a few weeks without treatment. The time from exposure to the onset of symptoms ranges from three to seventeen days, and symptoms typically last from two to four weeks. However, cases may be severe, especially in children, pregnant women, or people with suppressed immune systems.[3][4][5]

The disease is caused by the monkeypox virus, a zoonotic virus in the genus Orthopoxvirus. The variola virus, which causes smallpox, is also in this genus.[6] Human-to-human transmission can occur through direct contact with infected skin or body fluids, including sexual contact.[6] People remain infectious from the onset of symptoms until all the lesions have scabbed and healed.[3] The virus may spread from infected animals through handling infected meat or via bites or scratches.[3] Diagnosis can be confirmed by polymerase chain reaction (PCR) testing a lesion for the virus's DNA.[6]

Vaccination is recommended for those at high risk of infection.[6] No vaccine has been developed specifically against mpox, but smallpox vaccines have been found to be effective.[7] There is no specific treatment for the disease, so the aim of treatment is to manage the symptoms and prevent complications.[6][8] Antiviral drugs such as tecovirimat can be used to treat mpox,[6] although their effectiveness has not been proved.[9]

An ongoing outbreak of mpox was confirmed on 6 May 2022, beginning with a British resident who, after travelling to Nigeria (where the disease is endemic), presented symptoms consistent with mpox on 29 April 2022. The resident returned to the United Kingdom on 4 May, creating the country's index case of the outbreak.[10] The origin of several of the cases of mpox in the United Kingdom is unknown. Some monitors saw community transmission taking place in the London area as of mid-May,[11] but it has been suggested that cases were already spreading in Europe in the previous months.[12]

Transmission

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Stages of lesion development.

A large portion of those infected were believed to have not recently traveled to areas of Africa where mpox is normally found, such as Nigeria, the Democratic Republic of the Congo as well as central and western Africa. It is believed to be transmitted by close contact with sick people, with extra caution for those individuals with lesions on their skin or genitals, along with their bedding and clothing. The CDC has also stated that individuals should avoid contact and consumption of dead animals such as rats, squirrels, monkeys and apes along with wild game or lotions derived from animals in Africa.[13]

In addition to more common symptoms, such as fever, headache, swollen lymph nodes, and rashes or lesions, some patients have also experienced proctitis, an inflammation of the rectum lining. CDC has also warned clinicians to not rule out mpox in patients with sexually transmitted infections since there have been reports of co-infections with syphilis, gonorrhea, chlamydia, and herpes.[14]

History

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As of 22 August 2022, there have been 416 laboratory-confirmed cases of mpox in Switzerland.[15] On 24 August 2022, the Swiss Federal Council decided to order 40,000 vaccine doses from Bavarian Nordic.[16]

See also

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Notes

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References

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  1. ^ "Switzerland confirms its first case of monkeypox". Reuters. 21 May 2022.
  2. ^ "WHO recommends new name for monkeypox disease" (Press release). World Health Organization (WHO). 28 November 2022. Archived from the original on 1 December 2022. Retrieved 29 November 2022.
  3. ^ a b c "Mpox". World Health Organization (WHO). 17 August 2024. Archived from the original on 19 August 2024. Retrieved 22 August 2024.
  4. ^ "WHO Factsheet – Mpox (Monkeypox)". World Health Organization (WHO). 18 April 2023. Archived from the original on 21 April 2022. Retrieved 21 May 2023.
  5. ^ "Mpox Symptoms". U.S. Centers for Disease Control and Prevention (CDC). 15 March 2024. Archived from the original on 2 April 2024. Retrieved 22 August 2024.
  6. ^ a b c d e f "WHO Factsheet – Mpox (Monkeypox)". World Health Organization (WHO). 18 April 2023. Archived from the original on 21 April 2022. Retrieved 21 May 2023.
  7. ^ Christodoulidou MM, Mabbott NA (1 January 2023). "Efficacy of smallpox vaccines against Mpox infections in humans". Immunotherapy Advances. 3 (1): ltad020. doi:10.1093/immadv/ltad020. PMC 10598838. PMID 37886620.
  8. ^ "Mpox (formerly Monkeypox)". NIH: National Institute of Allergy and Infectious Diseases. 6 December 2022. Archived from the original on 23 May 2023. Retrieved 24 May 2023.
  9. ^ "Patient's Guide to Mpox Treatment with Tecovirimat (TPOXX)". U.S. Centers for Disease Control and Prevention (CDC). 28 November 2022. Archived from the original on 24 May 2023. Retrieved 24 May 2023.
  10. ^ "Monkeypox – United Kingdom of Great Britain and Northern Ireland". World Health Organization. 16 May 2022. Archived from the original on 17 May 2022. Retrieved 17 May 2022.
  11. ^ Pinkstone, Joe (17 May 2022). "Monkeypox 'spreading in sexual networks'". The Telegraph. Archived from the original on 17 May 2022. Retrieved 17 May 2022.
  12. ^ Nsofor, Ifeanyi (2 June 2022). "OPINION: Media coverage of monkeypox paints it as an African virus. That makes me mad". NPR. Retrieved 2 June 2022.
  13. ^ Vargas, Ramon Antonio (7 June 2022). "US raises monkeypox alert level but says risk to public remains low". the Guardian. Retrieved 9 June 2022.
  14. ^ "Monkeypox update: Where the outbreak stands now".
  15. ^ "Affenpocken Schweiz: 416 laborbestätigte Fälle" [Monkeypox Switzerland: 416 laboratory-confirmed cases]. www.mittellaendische.ch. 22 August 2022. Retrieved 24 August 2022.
  16. ^ "Schweiz will den Impfstoff gegen die Affenpocken auch ohne Zulassung" [Switzerland wants monkeypox vaccine even without approval]. www.aargauerzeitung.ch (in German). 24 August 2022. Retrieved 30 August 2022.
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