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Monoamine neurotoxin

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Oxidopamine (6-hydroxydopamine), a selective dopaminergic and noradrenergic neurotoxin.

A monoamine neurotoxin, or monoaminergic neurotoxin, is a drug that selectively damages or destroys monoaminergic neurons.[1] Monoaminergic neurons are neurons that signal via stimulation by monoamine neurotransmitters including serotonin, dopamine, and norepinephrine.[1] Examples of monoamine neurotoxins include the serotonergic neurotoxins para-chloroamphetamine (PCA), methylenedioxyamphetamine (MDMA), and 5,7-dihydroxytryptamine (5,7-DHT);[2] the dopaminergic neurotoxins oxidopamine (6-hydroxydopamine), MPTP, and methamphetamine; and the noradrenergic neurotoxins oxidopamine and DSP-4.[1] Dopaminergic neurotoxins can induce a Parkinson's disease-like condition in animals and humans.[1][3] Serotonergic neurotoxins have been associated with cognitive and memory deficits and psychiatric changes.[4][5][6][7]

List of monoamine neurotoxins

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Serotonergic neurotoxins

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Phenethylamines

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Tryptamines

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2-Aminoindans

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Dopaminergic neurotoxins

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Phenethylamines

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Pesticides

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Noradrenergic neurotoxins

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Others

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See also

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References

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  1. ^ a b c d e f g h i j k l m n o p q r s t u Kostrzewa RM (2022). "Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic Neurons". Handbook of Neurotoxicity. Cham: Springer International Publishing. pp. 159–198. doi:10.1007/978-3-031-15080-7_53. ISBN 978-3-031-15079-1.
  2. ^ a b c d e f g h Baumgarten HG, Lachenmayer L (2004). "Serotonin neurotoxins--past and present". Neurotox Res. 6 (7–8): 589–614. doi:10.1007/BF03033455. PMID 15639791.
  3. ^ Grünblatt E, Mandel S, Youdim MB (April 2000). "MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies". J Neurol. 247 (Suppl 2): II95–102. doi:10.1007/pl00022909. PMID 10991672.
  4. ^ Parrott AC (April 2002). "Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity". Pharmacol Biochem Behav. 71 (4): 837–844. doi:10.1016/s0091-3057(01)00711-0. PMID 11888574.
  5. ^ Parrott AC (September 2013). "MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users". Neurosci Biobehav Rev. 37 (8): 1466–1484. doi:10.1016/j.neubiorev.2013.04.016. PMID 23660456.
  6. ^ a b Aguilar MA, García-Pardo MP, Parrott AC (January 2020). "Of mice and men on MDMA: A translational comparison of the neuropsychobiological effects of 3,4-methylenedioxymethamphetamine ('Ecstasy')". Brain Res. 1727: 146556. doi:10.1016/j.brainres.2019.146556. PMID 31734398.
  7. ^ Montgomery C, Roberts CA (January 2022). "Neurological and cognitive alterations induced by MDMA in humans" (PDF). Exp Neurol. 347: 113888. doi:10.1016/j.expneurol.2021.113888. PMID 34624331.
  8. ^ a b c d Biel JH, Bopp BA (1978). "Amphetamines: Structure-Activity Relationships". Stimulants. Boston, MA: Springer US. p. 1–39. doi:10.1007/978-1-4757-0510-2_1. ISBN 978-1-4757-0512-6.
  9. ^ Fuller RW, Baker JC (November 1974). "Long-lasting reduction of brain 5-hydroxytryptamine concentration by 3-chloramphetamine and 4-chloroamphetamine in iprindole-treated rats". J Pharm Pharmacol. 26 (11): 912–914. doi:10.1111/j.2042-7158.1974.tb09206.x. PMID 4156568.
  10. ^ a b c d e f g Nichols DE, Marona-Lewicka D, Huang X, Johnson MP (1993). "Novel serotonergic agents" (PDF). Drug des Discov. 9 (3–4): 299–312. PMID 8400010.
  11. ^ a b c d e Oeri HE (May 2021). "Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy". J Psychopharmacol. 35 (5): 512–536. doi:10.1177/0269881120920420. PMC 8155739. PMID 32909493.
  12. ^ a b Seiden LS, Sabol KE (1996). "Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction" (PDF). NIDA Res Monogr. 163: 251–276. PMID 8809863.
  13. ^ a b Itzhak Y, Achat-Mendes C (May 2004). "Methamphetamine and MDMA (ecstasy) neurotoxicity: 'of mice and men'". IUBMB Life. 56 (5): 249–255. doi:10.1080/15216540410001727699. PMID 15370888.
  14. ^ Harvey JA (June 1978). "Neurotoxic action of halogenated amphetamines". Ann N Y Acad Sci. 305 (1): 289–304. Bibcode:1978NYASA.305..289H. doi:10.1111/j.1749-6632.1978.tb31530.x. PMID 81648.
  15. ^ Iversen L, White M, Treble R (December 2014). "Designer psychostimulants: pharmacology and differences". Neuropharmacology. 87: 59–65. doi:10.1016/j.neuropharm.2014.01.015. PMID 24456744.
  16. ^ McCann UD, Seiden LS, Rubin LJ, Ricaurte GA (August 1997). "Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence". JAMA. 278 (8): 666–672. doi:10.1001/jama.1997.03550080076043. PMID 9272900.
  17. ^ Rothman RB, Baumann MH (April 2002). "Serotonin releasing agents. Neurochemical, therapeutic and adverse effects". Pharmacol Biochem Behav. 71 (4): 825–836. doi:10.1016/s0091-3057(01)00669-4. PMID 11888573.
  18. ^ a b Johnson MP, Nichols DE (May 1990). "Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine". Pharmacol Biochem Behav. 36 (1): 105–109. doi:10.1016/0091-3057(90)90133-3. PMID 2140899.
  19. ^ Caccia S, Anelli M, Ferrarese A, Fracasso C, Garattini S (March 1993). "The role of d-norfenfluramine in the indole-depleting effect of d-fenfluramine in the rat". Eur J Pharmacol. 233 (1): 71–77. doi:10.1016/0014-2999(93)90350-q. PMID 7682511.
  20. ^ Sainsbury PD, Kicman AT, Archer RP, King LA, Braithwaite RA (2011). "Aminoindanes--the next wave of 'legal highs'?". Drug Test Anal. 3 (7–8): 479–482. doi:10.1002/dta.318. PMID 21748859.
  21. ^ Corkery JM, Elliott S, Schifano F, Corazza O, Ghodse AH (July 2013). "MDAI (5,6-methylenedioxy-2-aminoindane; 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine; 'sparkle'; 'mindy') toxicity: a brief overview and update". Hum Psychopharmacol. 28 (4): 345–355. doi:10.1002/hup.2298. PMID 23881883.
  22. ^ a b c d Igarashi K (1998). "The Possible Role of an Active Metafbollte Derived from the Neuroleptic Agent Haloperidol in Drug-Induced Parkinsonism". Journal of Toxicology: Toxin Reviews. 17 (1): 27–38. doi:10.3109/15569549809006488. ISSN 0731-3837.
  23. ^ a b c Cao Y, Li B, Ismail N, Smith K, Li T, Dai R, et al. (November 2021). "Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins". Int J Mol Sci. 22 (23): 12805. doi:10.3390/ijms222312805. PMC 8657695. PMID 34884606.
  24. ^ a b Glinka Y, Gassen M, Youdim MB (1997). "Mechanism of 6-hydroxydopamine neurotoxicity". J Neural Transm Suppl. Journal of Neural Transmission. Supplementa. 50: 55–66. doi:10.1007/978-3-7091-6842-4_7. ISBN 978-3-211-82898-4. PMID 9120425.
  25. ^ Hernandez-Baltazar D, Zavala-Flores LM, Villanueva-Olivo A (October 2017). "The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model". Neurologia. 32 (8): 533–539. doi:10.1016/j.nrl.2015.06.011. PMID 26304655.
  26. ^ a b Varešlija D, Tipton KF, Davey GP, McDonald AG (February 2020). "6-Hydroxydopamine: a far from simple neurotoxin". J Neural Transm (Vienna). 127 (2): 213–230. doi:10.1007/s00702-019-02133-6. PMID 31894418.
  27. ^ Kurnik-Łucka M, Panula P, Bugajski A, Gil K (February 2018). "Salsolinol: an Unintelligible and Double-Faced Molecule-Lessons Learned from In Vivo and In Vitro Experiments". Neurotox Res. 33 (2): 485–514. doi:10.1007/s12640-017-9818-6. PMC 5766726. PMID 29063289.
  28. ^ a b Przedborski S, Vila M (2001). "MPTP: a review of its mechanisms of neurotoxicity". Clinical Neuroscience Research. 1 (6): 407–418. doi:10.1016/S1566-2772(01)00019-6.
  29. ^ a b c Arsuffi-Marcon R, Souza LG, Santos-Miranda A, Joviano-Santos JV (March 2024). "Neurotoxicity of Pyrethroids in neurodegenerative diseases: From animals' models to humans' studies". Chem Biol Interact. 391: 110911. Bibcode:2024CBI...39110911A. doi:10.1016/j.cbi.2024.110911. PMID 38367681.
  30. ^ Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, et al. (March 2016). "Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration". Mol Neurobiol. 53 (2): 995–1008. doi:10.1007/s12035-014-9057-2. PMC 5333774. PMID 25575680.
  31. ^ Jiao Z, Wu Y, Qu S (2020). "Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system". Cell Death Discov. 6: 78. doi:10.1038/s41420-020-00313-y. PMC 7447795. PMID 32884840.
  32. ^ a b c d Bastías-Candia S, Zolezzi JM, Inestrosa NC (February 2019). "Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model". Mol Neurobiol. 56 (2): 1044–1055. doi:10.1007/s12035-018-1148-z. PMID 29862459.
  33. ^ Kuter K, Smiałowska M, Wierońska J, Zieba B, Wardas J, Pietraszek M, et al. (June 2007). "Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats". Brain Res. 1155: 196–207. doi:10.1016/j.brainres.2007.04.018. PMID 17493592.
  34. ^ Ross SB, Stenfors C (January 2015). "DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action". Neurotox Res. 27 (1): 15–30. doi:10.1007/s12640-014-9482-z. PMID 24964753.
  35. ^ Jaim-Etcheverry G, Zieher LM (April 1980). "DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats". Brain Res. 188 (2): 513–523. doi:10.1016/0006-8993(80)90049-9. PMID 7370771.
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