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Rothberg Institute for Childhood Diseases

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Rothberg Institute for Childhood Diseases
Formation2002
FounderJonathan Rothberg
Type501(c)(3)
HeadquartersGuilford, Connecticut
Websitehttp://www.childhooddiseases.org/

The Rothberg Institute For Childhood Diseases is a non-profit organization dedicated to finding a cure for rare childhood diseases such as Tuberous Sclerosis Complex (TSC). The organization was founded by Jonathan Rothberg and his wife in 2002 after their son was born with TSC.[1][2][3][4]

Located in Guilford, Connecticut, the organization was responsible for the CommunityTSC distributed computing project.

Dr. Rothberg graduated from Yale University in 1991.[3]

CommunityTSC

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CommunityTSC Drug Design Optimization Lab (D2OL) was a distributed computing project developed by the Institute to test drug candidates interaction with a target molecule that is essential to the spread of the disease under scrutiny. By evaluating the energy level released by binding a small molecule drug candidate to the surface of a larger Target molecule (D2OL) determines the fitness of the particular candidate to a region of the Target structure known as the Active Site. This process is referred to as docking the drug candidate to the target. D2OL ended on April 15, 2009.

References

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  1. ^ "Yale Medicine Winter 2007: Alumni". Archived from the original on 2007-05-09. Retrieved 2016-11-14.
  2. ^ Pollack, Andrew (2011-01-05). "Taking DNA Sequencing to the Masses". The New York Times. ISSN 0362-4331. Retrieved 2023-02-23.
  3. ^ a b Belli, Brita (2018-03-20). "Alumnus Rothberg enlists students to solve next healthcare challenges". YaleNews. Retrieved 2023-06-20.
  4. ^ Pollack, Andrew (2011-01-05). "Taking DNA Sequencing to the Masses". The New York Times. ISSN 0362-4331. Retrieved 2023-06-20.
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