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Dihydroxy-acid dehydratase

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dihydroxy-acid dehydratase
Identifiers
EC no.4.2.1.9
CAS no.9024-32-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme dihydroxy-acid dehydratase (EC 4.2.1.9) catalyzes the chemical reaction

2,3-dihydroxy-3-methylbutanoate 3-methyl-2-oxobutanoate + H2O

This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.

Nomenclature

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This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include

  • acetohydroxyacid dehydratase,
  • α,β-dihydroxyacid dehydratase,
  • 2,3-dihydroxyisovalerate dehydratase,
  • α,β-dihydroxyisovalerate dehydratase,
  • dihydroxy acid dehydrase,
  • DHAD,
  • and 2,3-dihydroxy-acid hydro-lyase.

References

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Further reading

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  • Kanamori M, Wixom RL (Mar 1963). "Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves". The Journal of Biological Chemistry. 238: 998–1005. PMID 13962154.
  • Myers JW (May 1961). "Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine". The Journal of Biological Chemistry. 236: 1414–8. PMID 13727223.