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Merafloxacin

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Merafloxacin
Identifiers
  • 1-Ethyl-7-[3-(ethylaminomethyl)pyrrolidin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H23F2N3O3
Molar mass379.408 g·mol−1
3D model (JSmol)
  • CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CC)F
  • InChI=1S/C19H23F2N3O3/c1-3-22-8-11-5-6-24(9-11)17-14(20)7-12-16(15(17)21)23(4-2)10-13(18(12)25)19(26)27/h7,10-11,22H,3-6,8-9H2,1-2H3,(H,26,27)
  • Key:BAYYCLWCHFVRLV-UHFFFAOYSA-N

Merafloxacin is a fluoroquinolone antibacterial that inhibits the pseudoknot formation which is necessary for the frameshift in the SARS-CoV-2 genome.[1] It is a promising drug candidate for SARS-CoV-2.[2]

References

[edit]
  1. ^ Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, et al. (June 2021). "Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome". Science. 372 (6548): 1306–1313. Bibcode:2021Sci...372.1306B. doi:10.1126/science.abf3546. PMC 8168617. PMID 34029205.
  2. ^ Sun Y, Abriola L, Surovtseva YV, Lindenbach BD, Guo JU (October 2020). "Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro". bioRxiv. doi:10.1101/2020.10.21.349225. PMC 7587830. PMID 33106809.