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Ectonucleoside triphosphate diphosphohydrolase 7

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(Redirected from ENTPD7)
ENTPD7
Identifiers
AliasesENTPD7, LALP1, ectonucleoside triphosphate diphosphohydrolase 7
External IDsOMIM: 616753; MGI: 2135885; HomoloGene: 122202; GeneCards: ENTPD7; OMA:ENTPD7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020354
NM_001349962
NM_001349963

NM_053103

RefSeq (protein)

NP_065087
NP_001336891
NP_001336892

NP_444333

Location (UCSC)Chr 10: 99.66 – 99.71 MbChr 19: 43.68 – 43.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 7 is a protein that in humans is encoded by the ENTPD7 gene.[5]

Function

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This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198018Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025192Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ectonucleoside triphosphate diphosphohydrolase 7". Retrieved 2018-05-11.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.