Jump to content

File:Bicalutamide and the hypothalamic-pituitary-glandular axes.png

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Original file (2,323 × 3,434 pixels, file size: 214 KB, MIME type: image/png)

Summary

Description
English: A diagram of the endocrine effects of bicalutamide and its influence on the hypothalamic-pituitary-glandular axes.
Date
Source

Adapted/remade from: (2004). "Bicalutamide (Casodex) in the treatment of prostate cancer". Expert Rev Anticancer Ther 4 (1): 37–48. DOI:10.1586/14737140.4.1.37. PMID 14748655. (See Figure 2. Endocrine effects of bicalutamide.)

I made this, anyone can use it. Made with draw.io.
Author Medgirl131

Code:

<mxGraphModel dx="1607" dy="669" grid="0" gridSize="10" guides="0" tooltips="1" connect="1" arrows="1" fold="1" page="0" pageScale="1" pageWidth="100" pageHeight="200" background="#ffffff" math="0" shadow="0">
  <root>
    <mxCell id="0"/>
    <mxCell id="1" parent="0"/>
    <mxCell id="49" value="" style="rounded=0;whiteSpace=wrap;html=1;align=right;fillColor=#dae8fc;strokeColor=#6c8ebf;" parent="1" vertex="1">
      <mxGeometry x="-103" y="539" width="320" height="160" as="geometry"/>
    </mxCell>
    <mxCell id="7" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=0;html=1;jettySize=auto;orthogonalLoop=1;labelPosition=left;verticalLabelPosition=middle;align=right;verticalAlign=middle;strokeColor=#000000;" parent="1" edge="1">
      <mxGeometry relative="1" as="geometry">
        <mxPoint x="57" y="127" as="sourcePoint"/>
        <mxPoint x="57" y="187" as="targetPoint"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="25" value="GnRH" style="text;html=1;resizable=0;points=[];align=center;verticalAlign=middle;labelBackgroundColor=#ffffff;" parent="7" vertex="1" connectable="0">
      <mxGeometry x="-0.3476" y="1" relative="1" as="geometry">
        <mxPoint x="34" y="9" as="offset"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="2" value="Hypothalamus" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;" parent="1" vertex="1">
      <mxGeometry x="-3" y="77" width="120" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="6" value="Pituitary Gland" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;" parent="1" vertex="1">
      <mxGeometry x="-3" y="197" width="120" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="21" value="" style="endArrow=none;startArrow=classic;html=1;align=right;endFill=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="-23" y="307" as="sourcePoint"/>
        <mxPoint x="17" y="247" as="targetPoint"/>
        <Array as="points"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="22" value="" style="endArrow=none;startArrow=classic;html=1;align=right;endFill=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="137" y="307" as="sourcePoint"/>
        <mxPoint x="95" y="247" as="targetPoint"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="23" value="Testes" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;" parent="1" vertex="1">
      <mxGeometry x="-83" y="317" width="120" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="24" value="Adrenal Glands" style="rounded=0;whiteSpace=wrap;html=1;glass=0;fillColor=#dae8fc;strokeColor=#6c8ebf;" parent="1" vertex="1">
      <mxGeometry x="77" y="317" width="120" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="26" value="Bicalutamide" style="text;html=1;resizable=0;points=[];align=center;verticalAlign=middle;labelBackgroundColor=#ffffff;" parent="1" vertex="1" connectable="0">
      <mxGeometry x="-11" y="146.42857142857144" as="geometry">
        <mxPoint x="23" y="9" as="offset"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="28" value="" style="endArrow=none;startArrow=classic;html=1;align=right;endFill=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="19" y="427" as="sourcePoint"/>
        <mxPoint x="-23" y="367" as="targetPoint"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="29" value="" style="endArrow=none;startArrow=classic;html=1;align=right;endFill=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="97" y="427" as="sourcePoint"/>
        <mxPoint x="137" y="367" as="targetPoint"/>
        <Array as="points"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="39" value="" style="edgeStyle=orthogonalEdgeStyle;rounded=0;html=1;jettySize=auto;orthogonalLoop=1;labelPosition=left;verticalLabelPosition=middle;align=right;verticalAlign=middle;strokeColor=#000000;" parent="1" edge="1">
      <mxGeometry relative="1" as="geometry">
        <mxPoint x="57" y="468" as="sourcePoint"/>
        <mxPoint x="57" y="528" as="targetPoint"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="41" value="Circulating&lt;div&gt;Androgens&lt;/div&gt;" style="rounded=0;whiteSpace=wrap;html=1;spacingTop=-2;fillColor=#ffffff;strokeColor=none;opacity=50;" parent="1" vertex="1">
      <mxGeometry x="26" y="425" width="64" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="43" value="Testosterone" style="rounded=0;whiteSpace=wrap;html=1;strokeColor=none;fillColor=none;" parent="1" vertex="1">
      <mxGeometry x="-3" y="544.6060606060606" width="120" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="44" value="" style="endArrow=none;startArrow=classic;html=1;align=right;endFill=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="-23" y="648.6060606060606" as="sourcePoint"/>
        <mxPoint x="17" y="588.6060606060606" as="targetPoint"/>
        <Array as="points"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="45" value="" style="endArrow=none;startArrow=classic;html=1;align=right;endFill=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="137" y="648.6060606060606" as="sourcePoint"/>
        <mxPoint x="95" y="588.6060606060606" as="targetPoint"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="46" value="Estradiol" style="rounded=0;whiteSpace=wrap;html=1;fillColor=none;strokeColor=none;" parent="1" vertex="1">
      <mxGeometry x="-92" y="645.6060606060606" width="120" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="47" value="DHT" style="rounded=0;whiteSpace=wrap;html=1;fillColor=none;strokeColor=none;" parent="1" vertex="1">
      <mxGeometry x="77" y="645.6060606060606" width="120" height="40" as="geometry"/>
    </mxCell>
    <mxCell id="50" value="Aromatization" style="text;html=1;strokeColor=none;fillColor=none;align=center;verticalAlign=middle;whiteSpace=wrap;" parent="1" vertex="1">
      <mxGeometry x="-72" y="600" width="40" height="20" as="geometry"/>
    </mxCell>
    <mxCell id="52" value="5&lt;span&gt;α&lt;/span&gt;-Reductase" style="text;html=1;strokeColor=none;fillColor=none;align=center;verticalAlign=middle;whiteSpace=wrap;" parent="1" vertex="1">
      <mxGeometry x="131" y="600" width="80" height="20" as="geometry"/>
    </mxCell>
    <mxCell id="57" value="LH" style="text;html=1;resizable=0;points=[];align=center;verticalAlign=middle;labelBackgroundColor=#ffffff;" parent="1" vertex="1" connectable="0">
      <mxGeometry x="-51" y="262.39393939393943" as="geometry">
        <mxPoint x="25" y="9" as="offset"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="59" value="ACTH" style="text;html=1;resizable=0;points=[];align=center;verticalAlign=middle;labelBackgroundColor=#ffffff;" parent="1" vertex="1" connectable="0">
      <mxGeometry x="123" y="262.39393939393943" as="geometry">
        <mxPoint x="25" y="9" as="offset"/>
      </mxGeometry>
    </mxCell>
    <mxCell id="61" value="Extraglandular Tissues" style="text;html=1;strokeColor=none;fillColor=none;align=center;verticalAlign=middle;whiteSpace=wrap;glass=0;" parent="1" vertex="1">
      <mxGeometry x="-18" y="703" width="150" height="20" as="geometry"/>
    </mxCell>
    <mxCell id="66" value="" style="endArrow=classic;dashed=1;html=1;strokeColor=#000000;align=right;curved=1;endFill=1;strokeWidth=2;opacity=50;endSize=6;shadow=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="15" y="447" as="sourcePoint"/>
        <mxPoint x="-13" y="117" as="targetPoint"/>
        <Array as="points">
          <mxPoint x="-124" y="397"/>
          <mxPoint x="-124" y="157"/>
        </Array>
      </mxGeometry>
    </mxCell>
    <mxCell id="69" value="Circulating&lt;div&gt;Estrogens&lt;/div&gt;" style="text;html=1;strokeColor=none;fillColor=none;align=center;verticalAlign=middle;whiteSpace=wrap;glass=0;" parent="1" vertex="1">
      <mxGeometry x="-170" y="565" width="39" height="20" as="geometry"/>
    </mxCell>
    <mxCell id="72" value="" style="endArrow=classic;html=1;shadow=0;strokeColor=#000000;strokeWidth=1;align=right;curved=1;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="-65" y="666.8252656434474" as="sourcePoint"/>
        <mxPoint x="-153" y="596" as="targetPoint"/>
        <Array as="points">
          <mxPoint x="-125" y="661"/>
        </Array>
      </mxGeometry>
    </mxCell>
    <mxCell id="75" value="" style="endArrow=classic;dashed=1;html=1;strokeColor=#000000;align=right;curved=1;endFill=1;strokeWidth=2;opacity=50;endSize=6;shadow=0;" parent="1" edge="1">
      <mxGeometry width="50" height="50" relative="1" as="geometry">
        <mxPoint x="-160" y="552" as="sourcePoint"/>
        <mxPoint x="-13" y="97" as="targetPoint"/>
        <Array as="points">
          <mxPoint x="-216" y="376"/>
          <mxPoint x="-160" y="146"/>
        </Array>
      </mxGeometry>
    </mxCell>
    <mxCell id="76" value="Negative Feedback" style="text;html=1;strokeColor=none;fillColor=none;align=center;verticalAlign=middle;whiteSpace=wrap;glass=0;" parent="1" vertex="1">
      <mxGeometry x="-178" y="285" width="40" height="20" as="geometry"/>
    </mxCell>
  </root>
</mxGraphModel>

Licensing

Public domain This work has been released into the public domain by its author, Medgirl131 at English Wikipedia. This applies worldwide.
In some countries this may not be legally possible; if so:
Medgirl131 grants anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law.

Original upload log

The original description page was here. All following user names refer to en.wikipedia.
Date/Time Dimensions User Comment
2017-07-21 10:49 2323×3434× (218643 bytes) Medgirl131 Improved a little bit more.
2017-07-20 09:45 1818×2627× (178901 bytes) Medgirl131 Bigger.
2017-07-20 09:43 487×688× (46382 bytes) Medgirl131 {{PD-self}} I made this, anyone can use it. A diagram of the endocrine effects of [[bicalutamide]] and its influence on the hypothalamic-pituitary-glandular axes. Adapted/remade from: {{cite journal | vauthors = Fradet Y | title = Bicalutamide (Caso...

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

20 July 2017

image/png

c41803f94dca8f4675f3c24e4d384848a73ddd02

218,643 byte

3,434 pixel

2,323 pixel

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current23:25, 5 September 2018Thumbnail for version as of 23:25, 5 September 20182,323 × 3,434 (214 KB)OgreBot(BOT): Reverting to most recent version before archival
23:25, 5 September 2018Thumbnail for version as of 23:25, 5 September 20181,818 × 2,627 (175 KB)OgreBot(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2017-07-20 09:45:42 by Medgirl131
23:25, 5 September 2018Thumbnail for version as of 23:25, 5 September 2018487 × 688 (45 KB)OgreBot(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2017-07-20 09:43:54 by Medgirl131
19:48, 5 September 2018Thumbnail for version as of 19:48, 5 September 20182,323 × 3,434 (214 KB)Vanished user 0x8cSXE0x6Transferred from en.wikipedia via #commonshelper

The following page uses this file:

Global file usage

The following other wikis use this file:

Metadata