File:Functional domains of the CHD subfamily of ATP-dependent chromatin remodellers .png
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Summary
| Description |
English: The unique N-terminal domain of the CDH subfamily contains two chromodomains. The two lobe domains act in tandem as the translocase domain (Tr) and are connected by a peptide linker. NegC* (similar to NegC in ISWI) acts as an inhibitor to lobe movement and translocation until proper binding of the DNA-binding domain (DBD) occurs. NegC* acts by blocking ATP hydrolysis at the lobes. The DBD also acts as a nucleotide ruler, evenly spacing nucleosomes from one another. Post-DNA binding, the DBD causes tension on the DNA strand resulting in a conformational change that blocks regular NegC* inhibition. This allows for the activation of the TR domain, resulting in DNA translocation. |
| Date | |
| Source | Own work |
| Author | Nbrayton2016 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 16:40, 27 April 2020 | | 561 × 107 (6 KB) | Nbrayton2016 | Cross-wiki upload from en.wikipedia.org |
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