File:Hepatitis B virus v2 (2).svg
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Summary
Extended description
The structure of the Hepatitis B virus as first described by Dane & al.[1] and Jokelainen, Krohn & al.[2] in 1970:
Virion
The hepatitis B virion, is a complex, spherical, double shelled particle with a diameter of 42 nm.[1][2][3]
- The 6 nm[2] thick outer viral envelope or membrane contains host-derived lipids and surface proteins,[2] known collectively as HBsAg.[3] The membrane contains globular subunits each measuring ca. 3 to 4 nm in diameter and 3 to 4 nm apart.[2]
- Within the membrane sphere is a 2 nm thick icosahedral nucleocapsid inner core composed of protein (HBcAg) with a diameter of 27 nm.[2] When viewed through an electron microscope the inner core may appear pentagonal or hexagonal,[2] depending on the relative position of the sample.
- The nucleocapsid contains a viral genome[2] of circular, partially double stranded DNA[3] and endogenous DNA polymerase[4][3] within a diameter of ca. 18 nm.[2]
The virion was initially referred to as the Dane particle.[4] Only after Baruch Blumberg received the Nobel Prize in Medicine in 1976 was it universally accepted that the particle is a virus and the infectious agent of Hepatitis B.
Australia antigen (HBsAg)
The serum of infected patients also contain small spherical and rod-shaped particles with a diameter of ca. 20 nm,[5] consisting of surplus virus-coat material containing the HBsAg antigen.[1][2] This antigen was first discovered by Baruch Blumberg in 1965 in the blood of Australian aboriginal people and initially known as "Australia antigen".[6] It was shown to be associated with "serum hepatitis" by A. M. Prince in 1968.[7]
The outer membrane of the virion is sometimes extended as a tubular tail on one side of the virus particle (not shown);[2][3] these virion "tails" are identical to the small particles.[2][3]
The hepatitis B e antigens (shown) are considered not part of the viral particle.
References
- ↑ a b c D.S. Dane , C.H. Cameron , Moya Briggs (1970). "Virus-Like Particles in Serum of Patients with Australia-Antigen-Associated Hepatitis". The Lancet 295: 695–698. DOI:10.1016/S0140-6736(70)90926-8.
- ↑ a b c d e f g h i j k l P. T. Jokelainen, Kai Krohn, A. M. Prince and N. D. C. Finlayson (1970). "Electron Microscopic Observations on Virus-Like Particles Associated with SH Antigen". J Virol. 6 (5): 685-689. ISSN 1098-5514.
- ↑ a b c d e f The hepatitis B virus. WHO.
- ↑ a b Almeida J D, Rubenstein D & Scott E J. (1971). "New antigen-antibody system in Australia-antigen-positive hepatitis". The Lancet 298 (7736): 1225–7. DOI:10.1016/S0140-6736(71)90543-5.
- ↑ Bayer, M. E., B. S. Blumberg, and B. Werner (1968). "Particles associated with Australia antigen in the sera of patients with leukemia, Down's syndrome and hepatitis.". Nature (London) 218: 1057-1059.
- ↑ Baruch S. Blumberg, Harvey J. Alter, and Sam Visnich (Jul 1984). "Landmark article Feb 15, 1965: A 'new' antigen in leukemia sera. By Baruch S. Blumberg, Harvey J. Alter, and Sam Visnich". JAMA 252 (2): 252–7. DOI:10.1001/jama.252.2.252. PMID 6374187. ISSN 0098-7484.
- ↑ Prince, A. M. (1968). "An antigen detected in the blood during the incubation period of serum hepatitis". Proc. Nat. Acad. Sci. U.S.A. 60: 814-821.
| Description |
English: Simplified drawing of the Hepatitis B virus particle and surface (surplus) antigen. Created by en:User:GrahamColm |
| Date | 14 November 2007 (original upload date) |
| Source | Transferred from en.wikipedia |
| Author | Original uploader was TimVickers at en.wikipedia |
| Permission (Reusing this file) |
Released into the public domain (by the author). |
| Other versions |
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Licensing
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This work has been released into the public domain by its author, TimVickers, at the English Wikipedia project. This applies worldwide. In case this is not legally possible: |
Original upload log
- 2007-11-14 18:14 TimVickers 843×577× (81917 bytes) Simplified drawing of the Hepatitis B virus particle and surface (surplus) antigen
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 18:36, 23 January 2013 | | 754 × 428 (81 KB) | Graham Beards | Reverted to version as of 02:06, 10 December 2009 |
| 02:06, 10 December 2009 |  | 754 × 428 (81 KB) | Huckfinne | Made it into a .svg file and improved the labeling to the standards I've learned in medical school. |
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