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Summary

Description
English: Protein detoxification pathway

Protein arginine methylation is performed by a class of enzymes termed protein arginine methyltransferases (PRMT), which specifically methylate protein-incorporated L-arginine (L-Arg) residues to generate protein incorporated monomethylarginine (L-MMA), asymmetric dimethylarginine (ADMA), or symmetric dimethylarginine (SDMA).

Upon proteolytic cleavage of arginine-methylated proteins, free intracellular MMA, ADMA, or SDMA are generated. Free L-Arginine can be metabolized by arginases to L-ornithine and urea, or by nitric oxide synthases (NOS) to NO and L-citrulline.

Free methylarginines can also be released to the extracellular space by cationic amino acid transporters (CAT) to induce distinct biological effects, undergo hepatic metabolism, or renal excretion.

MMA and ADMA, but not SDMA can be converted to L-citrulline and mono- or diamines by a class of intracellular enzymes called dimethylarginine dimethylaminohydrolases (DDAH). Most importantly, MMA and ADMA, but not SDMA, act as potent endogenous inhibitors of NOS enzymes.
Source Ttingate (talk) (Uploads)
Author Dr Trevor Tingate

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Original upload log

Transferred from en.wikipedia to Commons using For the Common Good.

The original description page was here. All following user names refer to en.wikipedia.
Date/Time Dimensions User Comment
02:04, 28 June 2010 3,000 × 2,250 (281,182 bytes) w:en:Ttingate (talk | contribs) rotein arginine methylation is performed by a class of enzymes termed protein arginine methyltransferases (PRMT), which specifically methylate protein-incorporated L-arginine (L-Arg) residues to generate protein incorporated monomethylarginine (L-MMA), as
00:27, 28 June 2010 3,000 × 2,250 (281,182 bytes) w:en:Ttingate (talk | contribs)
00:24, 28 June 2010 3,000 × 2,250 (281,182 bytes) w:en:Ttingate (talk | contribs)
02:02, 25 June 2010 3,000 × 2,250 (281,182 bytes) w:en:Ttingate (talk | contribs)
00:54, 25 June 2010 960 × 720 (52,221 bytes) w:en:Ttingate (talk | contribs) Dr Trevor Tingate MD MBBS
04:40, 22 June 2010 965 × 725 (99,244 bytes) w:en:Ttingate (talk | contribs) redo
04:28, 22 June 2010 1,680 × 1,050 (75,599 bytes) w:en:Ttingate (talk | contribs) Zakrzewicz, D. From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases Pulmonary Medicine 2009;9:1471-2466 Methylarginine metabolism. Protein arginine methylation is performed by a class of enzymes terme

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Date/TimeThumbnailDimensionsUserComment
current17:43, 10 December 2016Thumbnail for version as of 17:43, 10 December 20163,000 × 2,250 (275 KB)OgreBot(BOT): Reverting to most recent version before archival
17:43, 10 December 2016Thumbnail for version as of 17:43, 10 December 2016960 × 720 (51 KB)OgreBot(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-25 00:54:15 by Ttingate
17:43, 10 December 2016Thumbnail for version as of 17:43, 10 December 2016965 × 725 (97 KB)OgreBot(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-22 04:40:18 by Ttingate
17:43, 10 December 2016Thumbnail for version as of 17:43, 10 December 20161,680 × 1,050 (74 KB)OgreBot(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-22 04:28:08 by Ttingate
15:58, 8 December 2016Thumbnail for version as of 15:58, 8 December 20163,000 × 2,250 (275 KB)Jon KolbertTransferred from en.wikipedia: see original upload log above

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