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GALNT1

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(Redirected from GalNAc-T1)
GALNT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGALNT1, GALNAC-T1, polypeptide N-acetylgalactosaminyltransferase 1
External IDsOMIM: 602273; MGI: 894693; HomoloGene: 8469; GeneCards: GALNT1; OMA:GALNT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020474

NM_001160404
NM_013814
NM_001361200

RefSeq (protein)

NP_065207

NP_001153876
NP_038842
NP_001348129

Location (UCSC)Chr 18: 35.58 – 35.71 MbChr 18: 24.34 – 24.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GALNT1 gene.[5][6][7]

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141429Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000420Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ White T, Bennett EP, Takio K, Sorensen T, Bonding N, Clausen H (Dec 1995). "Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase". J Biol Chem. 270 (41): 24156–65. doi:10.1074/jbc.270.41.24156. PMID 7592619.
  6. ^ Tenno M, Toba S, Kezdy FJ, Elhammer AP, Kurosaka A (Aug 2002). "Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)". Eur J Biochem. 269 (17): 4308–16. doi:10.1046/j.1432-1033.2002.03123.x. PMID 12199709.
  7. ^ a b "Entrez Gene: GALNT1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)".

Further reading

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