Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4gene.[5][6][7] It is also known as humanGolgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.
Human GAAP [8] is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca+2, an increase of GAAP can help prevent apoptosis.[9][10] GAAP is also involved in promoting cell migration[11][12] and has been identified as a novel Golgi cation channel.[13] Other GAAPs can be found in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.
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Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID17353931.
