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Integrin beta 5

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ITGB5
Identifiers
AliasesITGB5, Integrin, beta 5, integrin subunit beta 5
External IDsOMIM: 147561; MGI: 96614; HomoloGene: 20511; GeneCards: ITGB5; OMA:ITGB5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002213
NM_001354764
NM_001354765
NM_001354766

NM_001145884
NM_010580

RefSeq (protein)

NP_002204
NP_001341693
NP_001341694
NP_001341695

NP_001139356
NP_034710
NP_001391992

Location (UCSC)Chr 3: 124.76 – 124.9 MbChr 16: 33.65 – 33.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]

Interactions

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Integrin, beta 5 has been shown to interact with PTK2,[7] Annexin A5[8] and PAK4.[9]

Functions

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ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[10]

Clinical significance

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Research

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Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[11]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000082781Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022817Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi:10.1016/S0021-9258(17)44878-2. PMID 2211615.
  6. ^ "Entrez Gene: ITGB5 integrin, beta 5".
  7. ^ Eliceiri BP, Puente Xose S, Hood John D, Stupack Dwayne G, Schlaepfer David D, Huang Xiaozhu Z, Sheppard Dean, Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
  8. ^ Cardó-Vila M, Arap Wadih, Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.
  9. ^ Zhang H, Li Zhilun, Viklund Eva-Karin, Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.
  10. ^ Zhang Ly, Guo Q, Guan Gf, Cheng W, Cheng P, Wu Ah (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi:10.3389/fonc.2019.00904. ISSN 2234-943X. PMC 6764112. PMID 31616629.
  11. ^ Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. S2CID 5097233.

Further reading

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