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Hepatic fructokinase

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(Redirected from Ketohexokinase)
ketohexokinase (fructokinase)
Ketohexokinase homodimer, Human
Identifiers
SymbolKHK
NCBI gene3795
HGNC6315
OMIM229800
RefSeqNM_006488
UniProtP50053
Other data
EC number2.7.1.3
LocusChr. 2 p23.3-23.2
Search for
StructuresSwiss-model
DomainsInterPro
Ketohexokinase
Identifiers
EC no.2.7.1.3
CAS no.9030-50-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate.

ATP + Fru    ADP + F1P
ATP + D-fructose → ADP + D-fructose-1-phosphate[1]

Pathology

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A deficiency is associated with essential fructosuria.

References

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  1. ^ Bais R, James HM, Rofe AM, Conyers RA (1985). "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol". Biochem. J. 230 (1): 53–60. doi:10.1042/bj2300053. PMC 1152585. PMID 2996495.
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