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Long-chain-fatty-acid—(acyl-carrier-protein) ligase

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Long-chain-fatty-acid—[acyl-carrier-protein] ligase
Identifiers
EC no.6.2.1.20
CAS no.77322-37-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a long-chain-fatty-acid—[acyl-carrier-protein] ligase (EC 6.2.1.20) is an enzyme that catalyzes the chemical reaction

ATP + an acid + [acyl-carrier-protein] AMP + diphosphate + acyl-[acyl-carrier-protein]

The 3 substrates of this enzyme are ATP, acid, and acyl-carrier-protein, whereas its 3 products are AMP, diphosphate, and [[acyl-[acyl-carrier-protein]]].

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming). Other names in common use include acyl-[acyl-carrier-protein] synthetase, acyl-[acyl carrier protein] synthetase, acyl-ACP synthetase, acyl-[acyl-carrier-protein]synthetase, stearoyl-ACP synthetase, and acyl-acyl carrier protein synthetase. This enzyme participates in fatty acid metabolism.

References

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  • Ray TK, Cronan JE (1976). "Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 73 (12): 4374–8. doi:10.1073/pnas.73.12.4374. PMC 431460. PMID 794875.