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Protein-coding gene in the species Homo sapiens
Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene .[ 5] [ 6]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor . Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[ 6]
CRSP3 has been shown to interact with Estrogen receptor alpha ,[ 7] CEBPB [ 8] Cyclin-dependent kinase 8 .[ 7] [ 9]
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