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Microsomal triglyceride transfer protein

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(Redirected from MTTP)

MTTP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMTTP, ABL, MTP, Microsomal triglyceride transfer protein
External IDsOMIM: 157147; MGI: 106926; HomoloGene: 212; GeneCards: MTTP; OMA:MTTP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300785
NM_000253
NM_001386140

NM_001163457
NM_008642
NM_001355051
NM_001355052

RefSeq (protein)

NP_000244
NP_001287714

NP_001156929
NP_032668
NP_001341980
NP_001341981

Location (UCSC)Chr 4: 99.56 – 99.62 MbChr 3: 137.8 – 137.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP, also known as MTP, gene.[5][6]

MTTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein (MTP). Protein disulfide isomerase (PDI) completes the heterodimeric MTP, which has been shown to play a central role in lipoprotein assembly. Mutations in MTTP can cause abetalipoproteinemia.[6]

Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.[citation needed]

MTP adds triglycerides to nascent chylomicrons in the intestine, and to VLDL in the liver.[7]

Structure

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The large subunit of MTP, also known as the alpha subunit, contains an N-terminal half beta barrel, an alpha helix and a C-terminal lipid binding site that lies between two beta pleated sheets. It is a member of the large lipid transfer protein family, like apolipoprotein B (apo B), with which it interacts, but unlike apo B, it is not secreted. The heterodimer is instead retained in the endoplasmic reticulum due to the presence of a C-terminal KDEL motif on the PDI beta subunit.[8]

Interactive pathway map

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Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Statin pathway edit]]
Statin pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

Pharmacology

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Drugs that inhibit MTTP prevent the assembly of apo B-containing lipoproteins thus inhibiting the synthesis of chylomicrons and VLDL and leading to decrease in plasma levels of LDL-C.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138823Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028158Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S, Pease RJ, Cullen PM, et al. (Mar 1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein". Hum Mol Genet. 2 (12): 2109–16. doi:10.1093/hmg/2.12.2109. PMID 8111381.
  6. ^ a b "Entrez Gene: MTTP microsomal triglyceride transfer protein".
  7. ^ Katzung BG (2018). Basic & Clinical Pharmacology (14th ed.). McGraw-Hill Education. p. 638. ISBN 978-1-259-64115-2.
  8. ^ Biterova EI, Isupov MN, Keegan RM, Lebedev AA, Sohail AA, Liaquat I, Alanen HI, Ruddock LW (2019). "The crystal structure of human microsomal triglyceride transfer protein". Proceedings of the National Academy of Sciences of the United States of America. 116 (35): 17251–17260. Bibcode:2019PNAS..11617251B. doi:10.1073/pnas.1903029116. PMC 6717300. PMID 31395737.

Further reading

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