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MedImmune

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MedImmune, LLC
Company typeSubsidiary
IndustryPharmaceutical
Founded1988; 36 years ago (1988) (as Molecular Vaccines, Inc.)
1989; 35 years ago (1989) (as MedImmune, Inc.)
HeadquartersGaithersburg, Maryland, U.S.
ProductsSynagis
FluMist
ParentAstraZeneca
Websitewww.medimmune.com[dead link]

MedImmune, LLC was a wholly owned subsidiary of AstraZeneca before February 14, 2019, when it was announced that the MedImmune name and branding would be discontinued in favor of AstraZeneca.[1][2]

MedImmune was founded in 1988 as Molecular Vaccines, Inc, and was purchased in 2007 for $15.6 billion.[3] Its main offices were located in Gaithersburg, MD, Cambridge, UK, and Mountain View, CA.[4]

It produced Synagis, a drug for the prevention of respiratory infections in infants, which accounted for US$ 1.06 billion of its US$ 1.2 billion in revenue for 2005, and FluMist, a nasal spray influenza vaccine introduced in 2004. MedImmune acquired FluMist when it purchased Aviron in 2002 for US$ 1.5 billion. FluMist sales totaled US$ 104 million in 2008, US$ 54.8 million in 2007, and US$ 36.4 million in 2006.[5]

FluMist was approved for children two years of age and older in 2007, but initially was approved only for healthy people ages 5 to 49, a significant limitation because it eliminated a significant market—young children who find injections objectionable. Sales of FluMist fell short of analysts' expectations for the first two years the drug was sold. FluMist was initially sold in a frozen form, which was difficult for doctors to store.[6]

MedImmune conducted successful clinical trials for a new generation of FluMist needle-free vaccine, called CAIV-T, which was approved by the U.S. Food and Drug Administration (FDA) in 2007, and is now the form offered on the market.

History

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Molecular Vaccines, Inc. was founded by Wayne T. Hockmeyer, David Mott, and Dr. James Young in 1988.[6] In 1989, Molecular Vaccines, Inc changed its name to MedImmune, Inc.

On April 23, 2007, it was announced MedImmune and AstraZeneca entered into a definitive agreement under which AstraZeneca intended to acquire MedImmune in an all-cash transaction at US$ 58 per share, or about US$ 15.2 billion.[6] On 19 June 2007 AstraZeneca completed the acquisition paying US$ 15.2 billion primarily for its drug development pipeline. Analysts have criticised the take-over, claiming that AstraZeneca paid too much.[7] AstraZeneca chose to merge MedImmune with Cambridge Antibody Technology, which it had acquired in 2006, creating a new biologics division under the MedImmune name. AstraZeneca presented the new MedImmune to investors on 7 December 2007.[8]

In June 2007, the National Institutes of Health (NIH) began enrolling participants in a Phase 1 H5N1 study of an intranasal influenza vaccine candidate based on MedImmune's live, attenuated vaccine technology.[9]

MedImmune said it was making a significant, rapid response with a vaccine to the novel H1N1 variant of influenza, known as swine flu.[10] In June 2009 it won a Department of Health and Human Services (HHS) contract, worth $90m. Under the contract with HHS, MedImmune will continue to make its seasonal FluMist vaccine and also develop a vaccine targeted specifically at the novel H1N1 virus.[5] MedImmune then won a second contract to test its nasal spray flu technology as a viable treatment for the H1N1.[11]

MedImmune received approval from the U.S. FDA for its intranasal novel H1N1 influenza vaccine in September 2009.[10]

Pipeline

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MedImmune had over 120 drugs in development for conditions including lupus, COPD, asthma, and many types of cancer. Major phase III trials included:[12]

See also

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References and notes

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  1. ^ "12 years on, Astra draws a line under Medimmune". Evaluate.com. 2019-02-14. Retrieved 2019-02-15.
  2. ^ "AstraZeneca retires Medimmune name amid sales turnaround". BioPharma Dive. Retrieved 2019-02-16.
  3. ^ Pollack, Andrew (24 April 2007). "AstraZeneca Buys MedImmune for $15.6 Billion". Retrieved 2 June 2019 – via NYTimes.com.
  4. ^ "About Us | MedImmune". Archived from the original on 2017-08-30. Retrieved 2017-08-23.
  5. ^ a b Michael S. Rosenwald (June 2, 2009). "MedImmune Wins Key Contract To Develop Swine Flu Vaccine". The Washington Post. Retrieved October 23, 2009.
  6. ^ a b c
  7. ^ "AstraZeneca's $15 Billion Buy of MedImmune buy too costly, some say". Money.cnn.com. Retrieved 2 June 2019.
  8. ^ "Media Centre - AstraZeneca". Astrazeneca.com. Retrieved 2 June 2019.
  9. ^ MedImmune Press release MedImmune and National Institutes of Health Begin Clinical Testing of a Live, Attenuated Intranasal Vaccine Against an H5N1 Avian Influenza Virus published June 15, 2007
  10. ^ a b "MedImmune Influenza A (H1N1) Information". Archived from the original on September 24, 2009. Retrieved October 23, 2009.
  11. ^ Sinha, Vandana (13 July 2009). "MedImmune gets second H1N1 flu contract".
  12. ^ "Pipeline - AstraZeneca". Astrazeneca.com. Retrieved 2 June 2019.
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