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Multiple minute digitate hyperkeratosis

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(Redirected from Minute aggregate keratosis)
Multiple minute digitate hyperkeratosis
SpecialtyDermatology

Multiple minute digitate hyperkeratosis, also known as digitate keratoses, disseminated spiked hyperkeratosis, familial disseminated piliform hyperkeratosis, and minute aggregate keratosis is a rare cutaneous condition, with about half of cases being familial, inherited in an autosomal dominant fashion, while the other half are sporadic.[1]

Signs and symptoms

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Multiple minute digitate hyperkeratosis is mostly a nonfollicular digitate keratosis that affects the limbs and trunk. There is no impact on the face or palmoplantar surfaces. The lesions consist of skin-colored, yellow, brown, or white spicules that range in length from 0.5 to 5.0 mm and diameter from 0.3 to 3.0 mm. Occasionally, flat-topped, dome-shaped, or crateriform papules are also present.[2]

Causes

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Multiple minute digitate hyperkeratosis may be sporadic or familial.[2]

Diagnosis

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Histopathology reveals a stratum granulosum with varying thickness and localized orthokeratotic hyperkeratosis originating from a tented epidermis. Rarely, there have also been reports of superficial cutaneous lymphoplasmocytic infiltrates, parakeratosis, and epidermal invagination. A recurring characteristic that unites all of the cases that have been documented is the absence of follicular involvement.[3]

Reduced keratohyaline granules with varying numbers of Odland bodies are seen under electron microscopy.[3]

Treatment

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While improvements with various topical keratolytics and topical and oral retinoids have been reported, treatment is frequently ineffective or only temporary.[2]

See also

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References

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  1. ^ Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Clinical diagnosis by laboratory methods; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. p. 637. ISBN 0-7216-2921-0.
  2. ^ a b c Caccetta, Tony Philip; Dessauvagie, Ben; McCallum, Dugald; Kumarasinghe, Sujith Prasad (2012). "Multiple minute digitate hyperkeratosis: A proposed algorithm for the digitate keratoses". Journal of the American Academy of Dermatology. 67 (1). Elsevier BV: e49–e55. doi:10.1016/j.jaad.2010.07.023. ISSN 0190-9622. PMID 21050621.
  3. ^ a b Coutinho, Inês; Gameiro, Ana Rita; Gouveia, Miguel Pinto; Cardoso, José Carlos; Figueiredo, Américo (2015). "Multiple minute digitate hyperkeratosis - a peculiar entity". Anais Brasileiros de Dermatologia. 90 (3 suppl 1). FapUNIFESP (SciELO): 153–155. doi:10.1590/abd1806-4841.20153440. ISSN 0365-0596.

Further reading

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  • Pimentel, CL; Puig, L; García‐Muret, MP; Fernandez‐Figueras, MT; Alomar, A (2002). "Multiple minute digitate hyperkeratosis". Journal of the European Academy of Dermatology and Venereology. 16 (4). Wiley: 422–424. doi:10.1046/j.1468-3083.2002.00570_9.x. ISSN 0926-9959.
  • Rubegni, P.; De Aloe, G.; Pianigiani, E.; Cherubini-Di Simplicio, F.; Fimiani, M. (2001). "Two sporadic cases of idiopathic multiple minute digitate hyperkeratosis". Clinical and Experimental Dermatology. 26 (1). Oxford University Press (OUP): 53–55. doi:10.1046/j.1365-2230.2001.00762.x. ISSN 0307-6938.
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