Dicyclohexylurea
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(Redirected from N,N'-dicyclohexyl urea)
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Names | |
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Preferred IUPAC name
N,N′-Dicyclohexylurea | |
Other names
DCU
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.017.468 |
EC Number |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C13H24N2O | |
Molar mass | 224.348 g·mol−1 |
Melting point | 230 to 233 °C (446 to 451 °F; 503 to 506 K) |
Hazards | |
GHS labelling: | |
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Warning | |
H302 | |
P264, P270, P301+P312, P330, P501 | |
Safety data sheet (SDS) | External MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Dicyclohexylurea is an organic compound, specifically, a urea. It is the byproduct of the reaction of dicyclohexylcarbodiimide with amines or alcohols. It may be prepared by the reaction of cyclohexylamine and S,S-dimethyl dithiocarbonate.[1] 1,3-Dicyclohexyl urea (DCU) is a potent soluble epoxide hydrolase (sEH) inhibitor. It has been shown to lower systemic blood pressure by 22 ± 4 mmHg in SHR.[2]
References
[edit]- ^ Man-kit Leung; Jun-Liang Lai; King-Hang Lau; Hsiao-hua Yu; Hsiang-Ju Hsiao (1996). "S,S-Dimethyl Dithiocarbonate: A Convenient Reagent for the Synthesis of Symmetrical and Unsymmetrical Ureas" (PDF). The Journal of Organic Chemistry. 61 (12): 4175–4179. doi:10.1021/jo9522825. PMID 11667305.
- ^ Sarbani Ghosh, Po-Chang Chiang, Jan L. Wahlstrom, Hideji Fujiwara, Jon G. Selbo andSteven L. Roberds (2008). "Oral Delivery of 1,3-Dicyclohexylurea Nanosuspension Enhances Exposure and Lowers Blood Pressure in Hypertensive Rats". Basic & Clinical Pharmacology & Toxicology. 102 (5): 453–458. doi:10.1111/j.1742-7843.2008.00213.x. PMID 18312493.
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