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Poly(alpha-L-guluronate) lyase

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(Redirected from Poly(a-L-guluronate) lyase)
guluronate-specific alginate lyase
Identifiers
EC no.4.2.2.11
CAS no.64177-88-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

The enzyme guluronate-specific alginate lyase (EC 4.2.2.11, formerly called poly(α-L-guluronate) lyase) catalyzes the following process:

Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-α-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and α-L-uluronate at their reducing end.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is alginate α-L-guluronate—uronate lyase. Other names in common use include alginase II, guluronate lyase, L-guluronan lyase, L-guluronate lyase, poly-α-L-guluronate lyase, and polyguluronate-specific alginate lyase.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1UAI.

References

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  • Boyd J, Turvey JR (1977). "Isolation of poly-alpha-L-guluronate lyase from Klebsiella aerogenes". Carbohydr. Res. 57: 163–71. doi:10.1016/S0008-6215(00)81928-X. PMID 332364.
  • Davidson IW, Sutherland IW, Lawson CJ (1976). "Purification and properties of an alginate lyase from a marine bacterium". Biochem. J. 159 (3): 707–13. doi:10.1042/bj1590707. PMC 1164172. PMID 1008828.