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Related to receptor tyrosine kinase

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(Redirected from RYK (gene))

RYK
Identifiers
AliasesRYK, D3S3195, JTK5, JTK5A, RYK1, receptor-like tyrosine kinase, receptor like tyrosine kinase
External IDsOMIM: 600524; MGI: 101766; HomoloGene: 68287; GeneCards: RYK; OMA:RYK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005861
NM_002958

NM_001042607
NM_013649
NM_001284258

RefSeq (protein)

NP_001005861
NP_002949

NP_001036072
NP_001271187
NP_038677

Location (UCSC)Chr 3: 134.07 – 134.25 MbChr 9: 102.71 – 102.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.[5]

History

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The gene encoding mouse RYK was first identified in 1992.[6] Subsequently, cDNA encoding the RYK protein have been isolated from the following species.[7]

Structure

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In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal, extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.[7]

Function

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RYK is involved in regulation of axon growth during development of the nervous system.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163785Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032547Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "RYK receptor like tyrosine kinase [ Homo sapiens (human) ]". National Center for Biotechnology Information, U.S. National Library of Medicine. 13 March 2020. Retrieved 2 April 2020.
  6. ^ Hovens CM, Stacker SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818–11822. Bibcode:1992PNAS...8911818H. doi:10.1073/pnas.89.24.11818. PMC 50648. PMID 1334548.
  7. ^ a b Halford MM, Stacker SA (2001). "Revelations of the RYK receptor". BioEssays. 23 (1): 34–45. doi:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. PMID 11135307. S2CID 18535933.
  8. ^ Hollis ER, Ishiko N, Yu T, Lu CC, Haimovich A, Tolentino K, Richman A, Tury A, Wang SH, Pessian M, Jo E, Kolodkin A, Zou Y (2016). "Ryk controls remapping of motor cortex during functional recovery after spinal cord injury". Nature Neuroscience. 19 (5): 697–705. doi:10.1038/nn.4282. PMC 4847956. PMID 27065364.

Further reading

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