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Protein THEMIS

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THEMIS
Identifiers
AliasesTHEMIS, C6orf190, C6orf207, GASP, SPOT, TSEPA, bA325O24.3, bA325O24.4, thymocyte selection associated
External IDsOMIM: 613607; MGI: 2443552; HomoloGene: 72287; GeneCards: THEMIS; OMA:THEMIS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178666
NM_001305663
NM_001374699

RefSeq (protein)

NP_001010923
NP_001158157
NP_001158159
NP_001305460

NP_001292592
NP_848781
NP_001361628

Location (UCSC)Chr 6: 127.71 – 127.92 MbChr 10: 28.54 – 28.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein THEMIS is a protein encoded by the eponymous THEMIS gene.[5][6][7]

Function

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This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[8] Changes in THEMIS gene expression due to the rs138300818 variant promote the development of early-onset type 1 diabetes.[9]

Etimology

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THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.[10]

References

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  1. ^ a b c ENSG00000172673 GRCh38: Ensembl release 89: ENSG00000275122, ENSG00000172673Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049109Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, et al. (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nature Immunology. 10 (8): 848–856. doi:10.1038/ni.1766. PMC 2757056. PMID 19597499.
  6. ^ Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, et al. (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nature Immunology. 10 (8): 840–847. doi:10.1038/ni.1768. PMC 2848698. PMID 19597498.
  7. ^ Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, et al. (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nature Immunology. 10 (8): 831–839. doi:10.1038/ni.1769. PMC 2908989. PMID 19597497.
  8. ^ "Entrez Gene: thymocyte selection associated".
  9. ^ Sandholm N, Rubio García A, Pekalski ML, Inshaw JR, Cutler AJ, Todd JA (August 2022). "Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants". Scientific Reports. 12 (1): 14137. Bibcode:2022NatSR..1214137S. doi:10.1038/s41598-022-18296-4. PMC 9391468. PMID 35986039.
  10. ^ Zielinska E (2009-11-01). "Six degrees of science". The Scientist. Archived from the original on 2009-11-06. Retrieved 2009-11-03.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.