Talk:Adenosine/Archive 1

Archive 1

Citation, effects of adenosine on DA

Im not sure how to add a citation.

" Normally, adenosine inhibits the release of the neurotransmitter, dopamine (DA), resulting in increased fatigue and lack of spontaneous behavioral activity (Davis, 2003). (http://science.csustan.edu/stone/chem4400/SJBR/Acevedo.pdf) " Davis, J.M., et al. (2003). “Central nervous system effects of caffeine and adenosine on fatigue.” AJP: Regulatory, Integretative, and Comparative Physiology 284.2: 399-404. (http://ajpregu.physiology.org/content/284/2/R399.long#ref-33)

Untitled

What is transient heart block as described by one of the effects

It is a short-term disabling of the atrioventricular node's ability to conduct electrical impulses, preventing ventricular activation by the SA node, atria, or AV node. Podwich 07:28, 28 February 2007 (UTC)

They just administered it to me today (SVT attack); if it corresponds to the most likely symptom, it was my heart stopping and starting again. Nice big burning sensation.

Citations

The information in this article needs to be cited. Shairstin 01:40, 3 December 2006 (UTC)

I agree I'm unsure if the information here is correct. Particularly about the affects on the heart, an Adenosine stress test I believe is actually the constriction of coronary arteries which exaggerates any ischaemia without having to get the patient to exercise Robinsona (talk) 20:56, 12 November 2010 (UTC)

An additional side effect is heart arrest. This happened to me yesterday and although resuscitation was successful very stressing (well it was a stress test!). The medical facility was aware of this side effect and included it in their consent form.

link http://www.sfn.org/index.cfm?pagename=brainBriefings_adenosineAndSleep seems to have expired —Preceding unsigned comment added by Localshop (talk • contribs) 03:15, 14 July 2009 (UTC)

Unused image

Here is an orphaned public domain image: Image:Adenosine.png. --Strangerer (Talk) 21:45, 9 April 2007 (UTC)

Too abbreviated

Can anybody translate this sentence before reinsertion into Contraindications:

* A-flutter W/rvr - when it first presents with SVT

Mikael Häggström 13:05, 4 November 2007 (UTC)

Atrial flutter with rapid ventricular response OldZeb (talk) 03:28, 28 November 2007 (UTC)

Too Technical?

I realise that 'adenosine' isn't exactly a popularly-known word/substance, however, I'm concerned with this article being too technical for average readership/research. For instance, I noticed too many medical abbreviations used - especially ones that are not widely known (for instance, 'SVT' or 'RVR') and, although, I started expanding some of them and giving more detailed descriptions of other terms, I quickly felt like I was the lone worker in a field of berries.... in other words, it seemed like, no matter how much I tried to simplify things, there was too much terminology that, in any reasonable way, could not be simplified without a major, major revamp.

I always appreciate more in-depth info in articles such as this one, but I am asking others for their opinion before I tried to be too drastic with the article itself. Should it: 1. remain as-is; 2. be edited conservatively, getting rid of confusing abbreviations and defining some of the more heady terminology, or 3. Simplified for the benefit of the 'average reader', possibly at the expense of 'thinning out' the detail?

I'm curious what others think of this type of situation (dealing with this type of article, especially) and how they should be dealt with. itinerant_tuna (talk) 08:28, 5 March 2009 (UTC)

Somebody more technical than I should mention that it was just reported that increased levels of adenosine have been found after a session of acupuncture. See http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2562.html 74.105.52.232 (talk) 01:38, 31 May 2010 (UTC) —Preceding unsigned comment added by 74.105.52.232 (talk) 01:32, 31 May 2010 (UTC)

how is the word pronounced? —Preceding unsigned comment added by 24.113.36.134 (talk) 13:23, 31 May 2010 (UTC)

hey you guys...

i appreciate the time you put in writing this article, it is indeed of value...but a basic thing is not clearly addressed:Is this a substance that the human body manufactures:; is it available in common foods; or is it a pharmaceutical?19:35, 7 February 2011 (UTC) —Preceding unsigned comment added by 24.7.28.186 (talk) -Rich Peterson199.33.32.40 (talk) 00:52, 8 February 2011 (UTC)

adenosine is all three -1) a fundamental chemical component of cells and the energy processes as ATP (adenosine triphosphate) and ADP and AMP and others. 2) a simple chemical, not generally important as consumed, and 3) a pharmaceutical (Adenocard/adenosine)

Two common uses as a pharmaceutical are 1) SVT (SupraVentricular Tachycardia) which occurs and recurs in many otherwise healthy young people. The clock of the heart takes off and runs the heart at high rates, typically 160 to 220 beats per minute, which generally doesn't feel good, but could precipitate other cardiac problems. There are multiple treatments to convert the ryhthm back to normal. One is a rapid IV dose of adenosine. It is an interestingly unusual situation in that the drug is so rapidly metablolzed in the blood, that it mus reach the heart within a second or two or it does not work. Also its effects are very short, but that is what is needed for SVT. It frequently slows the rate drastically or almost stops a few seconds. Associated with this, but not caused by the slow rate itself, is an awful feeling like one is dying, that lasts only 5 or 10 seconds. Patients tolerate this just fine when properly warned that it is coming and will be brief. A second common use for adenosine is in nuclear medicine cardiac stress tests whereby a short, 4 minute IV infusion of adenosine is given and a tracer, for example sestamibi, is given then a scan of the heart over the next 30 minutes shows parts of the heart muscle and its arterial blood supply which may be compromised in a state of coronary artery disease. — Preceding unsigned comment added by Kirt (talk • contribs) 17:17, 2 June 2011 (UTC)

Do we understand neurotransmitter theory in this article?

Under the section "Action in the central nervous system", is:

"Generalized, adenosine has an inhibitory effect in the central nervous system (CNS). Caffeine's stimulatory effects, on the other hand, are primarily (although not entirely) credited to its inhibition of adenosine by binding to the same receptors, and therefore effectively blocking adenosine receptors in the CNS. This reduction in adenosine activity leads to increased activity of the neurotransmitters dopamine and glutamate."

What seems to go unnoted here is that adenosine levels are increased in response to some external event, call it event E. When caffeine is introduced to the nervous system it "spoofs" adenosine, making the system behave as though event E had occurred. Therefore I think the sentence "This reduction in adenosine activity leads to increased activity of the neurotransmitters dopamine and glutamate" is misleading because there is not a reduction in adenosine activity, but an apparent increase in adenosine activity caused by the misrepresentation of adenosine by caffeine.

Further, assuming that the sole function of caffeine is to mimick adenosine, can we really say that adenosine has an inhibitory effect and caffeine has a stimulatory effect? Perhaps the "stimulatory" effect is only a result of putting the cart before the horse. Let us hypothesize about two modules of the nervous system that compute two different things, call them A and B. A and B have evolved such that B follows the completion of A. A communicates its completion by causing the release into the nervous system of the transmitter Y. B does not start performing its function until it has received information as to the completion of A, i.e. when its neuroreceptors indicate the presence of Y. If transmitter Y is introduced into the system before the completion of A, B will proceed with its computation assuming completion of A, and the results will be something other than intended. Imagine it as a candy factory trying to put wrappers on candy that has not yet made it to the conveyor belt.

Could the above be what happens with caffeine and adenosine? The brain assumes that adenosine receptors are being activated for the reason that was always true in evolutionary history, but that is not the case.

Perhaps the section should be reworded to reflect a deeper understanding of the purpose of neurotransmitters, which is to transmit information of a prior occurrence. — Preceding unsigned comment added by WikiTony999 (talk • contribs) 21:24, 3 October 2011 (UTC)

Is this article too scientific in nature, or should it be more layman?

The use for the article space is mainly technical, therefore, it is somewhat presumptive that a baseline in the medical field and the uses of this compound is needed for a greater understanding of the subject matter. Discussion of the chemical compound and it's medical uses in a scholarly setting provides more useful material than a simplistic approach. For simple referent to Adenosine and it's functions in medicine, I'd suggest taking a course in advanced cardiac life support (ACLS) Nikto wha? 22:46, 5 May 2014 (UTC)

TerpeneOtto (talk) 20:41, 14 December 2016 (UTC) The introduction covers what I would expect the article to mention. It seems to get a little to specific about its uses in medicine and forgets to mention Cyclic AMP in my opinon.

Drug box to Chem box (Critical Data)

TerpeneOtto (talk) 20:41, 14 December 2016 (UTC) I propose that we change the Drug Data box to a Chem. data box. The drug box on this page limits our ability to publish critical information for research purposes. I can publish some of the physical properties including magnetic susceptibility if we adapt the box to a more suitable format.

good idea - maybe we need both boxes ? - Rod57 (talk) 19:38, 7 July 2017 (UTC)

TerpeneOtto (talk) 20:41, 14 December 2016 (UTC) It would also be incredible if we could publish the Ox/Red. potentials of ATP , ADP, AMP, and CAMP. without this critical data researchers will be unable to complete basic cell energy research.

More about chemical and where it comes from

Hello. I think that this article needs more info about both where it comes from (where animals get it in nature) and about the actual chemical itself. Currently the article talks mainly about it's use as a drug and its effects on humans. What do you guys think? EditSafe (talk) 04:16, 11 March 2017 (UTC)

Agree - Article could be renamed adenosine (as a drug) or beefed up with non-medical info eg more on its natural functions in various cell types, gene regulation, biosynthesis ... - Rod57 (talk) 19:35, 7 July 2017 (UTC)