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Btbd12

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Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

SpeciesMus musculus
MGIMGI:12345
EnsemblENSMUSG00000039738
VegaOTTMUSG00000017627
Genomic Location18:123456-123536 (-)

Allele

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Allele nameBtbd12tm1(EUCOMM)Wtsi
ProgramEUCOMM
Critical exonThis is exon 3 of 15 (Transcript ENSMUST0000040790) Ablatation of the floxed exon causes a frameshift mutation
A sample allele image
All available Targeted Sanger ES Cells
5 Targeted conditional clones 3 Targeted non-conditional clones
ES Cell clone used for phenotyping
ES Cell Name: EPD0027_2_A08 ES Cell Strain: C57Bl/6N ES Cell Line: JM8.N4

Sanger Mice

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Genetic BackgroundC57BL/6NTac/Den;C57BL/6-Tyr;C57BL/6N
Genotyping informationPrimers and conditions here...
Register interest at ...EMMA

Expression

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Adult Expression Strong expression observed in adult brain and male reproductive organsSample expression dataSample expression data
Age Profile Available Piccies
E10.5 No whole pic
E14.5 Yes

A sample phenotype expression mount

E18.5 No
Adult Yes

SC PNS skin NE oe eye bat sm bone Cartilage vs wat Trachea oesophagus lung thymus stomach si li colon pp spleen mln pancreas ag Kidney us mg ovaries oviduct uterus testis prostate vas

Phenotype

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Phenotype
Phenotyping pipelinelink to pipeline
Headline observations

Male and female homozygotes show reduced viability and are infertile. Female homs show decreased body weight and decreased nose-to-tail length

Progeny from het x het intercross (number of progeny and ratio)
WTHETHOM
119 (0.33)203 (0.57)37 (0.1)
This is the big table of breeding stats
Reduced nose-tail length in females, reduced body weight in females A sample phenotype graph 1A sample phenotype graph 2

Cool picture of shrunk testes

A sample phenotype image