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40S ribosomal protein S15

From Wikipedia, the free encyclopedia
RPS15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPS15, RIG, S15, ribosomal protein S15
External IDsOMIM: 180535; MGI: 98117; HomoloGene: 110643; GeneCards: RPS15; OMA:RPS15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001018
NM_001308226

NM_009091
NM_001310726

RefSeq (protein)

NP_001009
NP_001295155

NP_001297655
NP_033117

Location (UCSC)Chr 19: 1.44 – 1.44 MbChr 10: 80.13 – 80.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115268Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063457Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shiga K, Yamamoto H, Okamoto H (Jun 1990). "Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes". Proc Natl Acad Sci U S A. 87 (9): 3594–8. Bibcode:1990PNAS...87.3594S. doi:10.1073/pnas.87.9.3594. PMC 53948. PMID 2159154.
  6. ^ a b "Entrez Gene: RPS15 ribosomal protein S15".

Further reading

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[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 40S ribosomal protein S15