Alexander Gusev (scientist)

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Alexander Gusev
EducationColumbia University (PhD)
Scientific career
FieldsStatistical genetics
Oncogenomics
Human genetics
InstitutionsHarvard Medical School
ThesisQuantifying recent variation and relatedness in human populations (2012)
Doctoral advisorItsik Pe'er

Alexander (Sasha) Gusev is a computational biologist and an Assistant Professor of Medicine at Harvard Medical School.[1]

Research and career[edit]

Alexander Gusev has developed computational methods that use genetic data to decipher disease mechanisms.[2] For example, he has identified 34 new genes associated with increased risk of earliest-stage ovarian cancer.[3] He has developed computational methods that integrate molecular data to facilitate functional interpretation of findings from genome-wide association studies.[4] He has contributed to the development of the transcriptome-wide association study approach to mapping disease-associated genes.[5] In addition, he studies the interactions between germline (host) and somatic events (tumor) - which are typically studied separately - and their effects on cancer progression and treatment response to advance precision oncology.

Awards and honors[edit]

Selected publications[edit]

  • Integrative approaches for large-scale transcriptome-wide association studies. A Gusev, A Ko, H Shi, G Bhatia, W Chung, B Penninx, R Jansen, E Geus, et al. Nature Genetics. 48(3):245–252. doi:10.1038/ng.3506
  • Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. A Gusev, N Mancuso, H Won, M Kousi, HK Finucane, Y Reshef, L Song, et al. Nature Genetics. 50(4):538-548. doi:10.1038/s41588-018-0092-1
  • Quantifying genetic effects on disease mediated by assayed gene expression levels.Yao DW, O'Connor LJ, Price AL, Gusev A. Nature Genetics. 52(6):626-633. doi:10.1038/s41588-020-0625-2
  • Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms. Shetty A, Seo JH, Bell CA, O'Connor EP, Pomerantz MM, Freedman ML, Gusev A. The American Journal of Human Genetics. 108(11):2071-2085. doi:10.1016/j.ajhg.2021.09.008
  • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation. A Gusev, H Shi, G Kichaev, M Pomerantz, F Li et al. Nature Communications. doi:10.1038/ncomms10979
  • Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. A Gusev, SH Lee, G Trynka, H Finucane et al. The American Journal of Human Genetics. 95(5):535-52. doi:10.1016/j.ajhg.2014.10.004
  • Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations. J Carrot-Zhang, G Soca-Chafre, N Patterson,..., A Gusev, M Meyerson. Cancer Discovery. 11(3):591-598. doi:10.1158/2159-8290.CD-20-1165

References[edit]

  1. ^ "Alexander Gusev, PhD". Dana-Farber/Harvard Cancer Center. Retrieved 2022-01-01.
  2. ^ "Alexander (Sasha) Gusev publications indexed by Google Scholar". scholar.google.com. Retrieved 2022-01-02.
  3. ^ "Scientists identify genes tied to increased risk of ovarian cancer". Dana-Farber Cancer Institute. Retrieved 2022-01-01.
  4. ^ Cano-Gamez E, Trynka G (May 2020). "From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases". Frontiers in Genetics. 11: 424. doi:10.3389/fgene.2020.00424. PMC 7237642. PMID 32477401.
  5. ^ Li B, Ritchie MD (September 2021). "From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries". Frontiers in Genetics. 12: 713230. doi:10.3389/fgene.2021.713230. PMC 8515949. PMID 34659337.

External links[edit]

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