C. Wyatt Shields IV

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Charles Wyatt Shields IV is an American biomedical engineer and assistant professor at the University of Colorado Boulder in the Department of Chemical and Biological Engineering.[1] His research involves the rational design of colloidal and supracolloidal particles for applications in drug delivery and biosensing.[2]

Education[edit]

C. Wyatt Shields IV received a Bachelor of Science with High Distinction in Biomedical Engineering at the University of Virginia graduating in 2011. There he performed undergraduate research with Jeffrey Saucerman and William Walker.[3] He continued his education and research with Gabriel López as a graduate student in Biomedical Engineering at Duke University where he obtained his PhD in 2016. During the attainment of his PhD, Shields studied magnetic and acoustic methods for isolation and analysis of cells.[4]

Career[edit]

Shields his continued with postdoctoral research at North Carolina State University where he worked with Orlin Velev and Stefan Zauscher in 2017[5] and then at Harvard University with Samir Mitragotri in 2018. At Harvard's Wyss Institute, Shields developed cytokine-releasing macrophage "backpacks" that maintain a tumor-killing state in cells, travel to tumor sites, and slow their growth.[6][7][8]

Shields became an assistant professor at the University of Colorado Boulder in 2020 in chemical and biological engineering.[8] He is also an affiliate professor in the biomedical engineering program and in the materials science and engineering programs. Working at the intersection of materials, soft matter physics and bioengineering, Shields has focused on understanding how stimuli-responsive particles behave in physiological settings in controlling their assembly and motion for biological applications.[1] His lab has numerous clinical collaborations.[9] Current research includes investigating the role of immune cells in decompression sickness using lung-on-a-chip devices,[10][11] developing "bottom-up" multifunctional magnetic microrobots,[12][13] and using acoustically responsive particles for capture and purification of disease biomarkers.[14]

Shields' early career has been highly successful, with numerous high profile awards, 5 patents filed,[15] and over 40 articles published in journals such as Science Advances,[16][17] Advanced Materials,[18] Advanced Functional Materials,[19] and Journal of Controlled Release.[20] Additionally, he is a Guest Associate Editor for the journal Bioengineering & Translational Medicine.

Shields' career has distinguished itself also for is his commitment to scientific outreach and mentorship. His group for several years, has worked with a local high school to provide engineering problems related to his lab's work in drug delivery and biosensing, permitting students the opportunity to design prototypes and work on real life engineering problems.[21] Shields also has been recognized for his mentorship of students of diverse and underrepresented backgrounds while working under Dr. Gabriel López[22] in 2016.

Awards and honors[edit]

In his third year at the University of Colorado Boulder, Shields received five distinguished research awards, including a National Science Foundation (NSF) CAREER award,[21][23][24] Office of Naval Research (ONR) Young Investigator Program award,[25] Pew Biomedical Scholars award,[26][27] Packard Fellowship for Science and Engineering,[13] and an NIH National Institute of General Medical Sciences (NIGMS) Maximizing Investigators' Research Award (MIRA).[13] Shields is one of only 20 recipients of the prestigious Packard Fellowship at the University of Colorado Boulder.[28]

Other awards and honors include:

  • CU Boulder Lab Venture Challenge Awardee (2022)[29]
  • Outreach Partner of the Year, Northglenn High School (2022)
  • Beckman Young Investigator Award Finalist (2022)
  • NIH Exploratory/Developmental Research Grant Award (2021)[14]
  • Best On-Demand Talk by the Controlled Release Society (2020)
  • Dean’s Award for Excellence in Mentoring, Duke University (2016)[22]
  • NSF Graduate Research Fellowship (2012)[30]
  • NSF Research Triangle MRSEC Fellowship (2011)[22]

References[edit]

  1. ^ a b "C. Wyatt Shields IV". Chemical and Biological Engineering. 2018-09-19. Retrieved 2022-12-03.
  2. ^ "Home | Shields Lab". www.colorado.edu. Retrieved 2022-12-03.
  3. ^ Han, Koohee; Shields, C. Wyatt; Velev, Orlin D. (18 December 2017). "Engineering of Self‐Propelling Microbots and Microdevices Powered by Magnetic and Electric Fields". Advanced Functional Materials. 28 (25): 1705953. doi:10.1002/adfm.201705953. ISSN 1616-301X. S2CID 103633421.
  4. ^ Iv, Shields; Wyatt, Charles (2016). "Acoustic and Magnetic Techniques for the Isolation and Analysis of Cells in Microfluidic Platforms". {{cite journal}}: Cite journal requires |journal= (help)
  5. ^ University, North Carolina State. "Microbot origami can capture, transport single cells". phys.org. Retrieved 2022-12-04.
  6. ^ Ktori, Sophia (2020-04-30). "Cytokine "Backpacks" Keep Macrophages in Cancer-Killing State". GEN - Genetic Engineering and Biotechnology News. Retrieved 2022-12-04.
  7. ^ "Researchers Develop Macrophage 'Backpacks' to Combat Tumors in Mice". BioSpace. Retrieved 2022-12-04.
  8. ^ a b ""Backpacks" boost immune cells' ability to kill cancer". seas.harvard.edu. Retrieved 2022-12-04.
  9. ^ "New collaborative grants advance innovative interdisciplinary research to improve human health and well-being". Research & Innovation Office. 2022-06-02. Retrieved 2022-12-04.
  10. ^ Group, SAE Media. "University of Colorado Boulder". www.techbriefs.com. Retrieved 2022-12-04.
  11. ^ "Fighting "the bends": Shields receives Office of Naval Research Young Investigator Program Award for decompression sickness study". Chemical and Biological Engineering. 2022-03-07. Retrieved 2022-12-04.
  12. ^ packardwpadmin (2022-10-18). "Meet the 2022 Class of Packard Fellows for Science and Engineering". The David and Lucile Packard Foundation. Retrieved 2022-12-04.
  13. ^ a b c "CU Boulder's Wyatt Shields wins 2022 Packard Fellowship for microscale robotics". Chemical and Biological Engineering. 2022-10-19. Retrieved 2022-12-04.
  14. ^ a b "Shields Lab receives NIH grant to help quickly diagnose fungal infections". Chemical and Biological Engineering. 2021-05-18. Retrieved 2022-12-04.
  15. ^ "C. Wyatt Shields IV". scholar.google.com. Retrieved 2022-12-04.
  16. ^ Shields, C. Wyatt; Evans, Michael A.; Wang, Lily Li-Wen; Baugh, Neil; Iyer, Siddharth; Wu, Debra; Zhao, Zongmin; Pusuluri, Anusha; Ukidve, Anvay; Pan, Daniel C.; Mitragotri, Samir (29 Apr 2020). "Cellular backpacks for macrophage immunotherapy". Science Advances. 6 (18): eaaz6579. Bibcode:2020SciA....6.6579S. doi:10.1126/sciadv.aaz6579. ISSN 2375-2548. PMC 7190308. PMID 32494680.
  17. ^ Han, Koohee; Shields, C. Wyatt; Diwakar, Nidhi M.; Bharti, Bhuvnesh; López, Gabriel P.; Velev, Orlin D. (2017-08-04). "Sequence-encoded colloidal origami and microbot assemblies from patchy magnetic cubes". Science Advances. 3 (8): e1701108. Bibcode:2017SciA....3E1108H. doi:10.1126/sciadv.1701108. ISSN 2375-2548. PMC 5544397. PMID 28798960.
  18. ^ Shields, C. Wyatt; Wang, Lily Li‐Wen; Evans, Michael A.; Mitragotri, Samir (28 June 2019). "Materials for Immunotherapy". Advanced Materials. 32 (13): 1901633. doi:10.1002/adma.201901633. ISSN 0935-9648. PMID 31250498. S2CID 195765229.
  19. ^ Shields, Charles Wyatt; Han, Koohee; Ma, Fuduo; Miloh, Touvia; Yossifon, Gilad; Velev, Orlin D. (5 July 2018). "Supercolloidal Spinners: Complex Active Particles for Electrically Powered and Switchable Rotation". Advanced Functional Materials. 28 (35): 1803465. doi:10.1002/adfm.201803465. ISSN 1616-301X. S2CID 103270967.
  20. ^ Shields, C. Wyatt; White, John P.; Osta, Erica G.; Patel, Jerishma; Rajkumar, Shashank; Kirby, Nickolas; Therrien, Jean-Philippe; Zauscher, Stefan (2018-05-28). "Encapsulation and controlled release of retinol from silicone particles for topical delivery". Journal of Controlled Release. 278: 37–48. doi:10.1016/j.jconrel.2018.03.023. ISSN 0168-3659. PMID 29604311. S2CID 4792307.
  21. ^ a b "Shields earns NSF CAREER Award for biomarkers research tied to high school outreach". Chemical and Biological Engineering. 2022-03-01. Retrieved 2022-12-04.
  22. ^ a b c School, The Graduate. "C. Wyatt Shields IV, 2016 Dean's Award Winner". gradschool.duke.edu. Retrieved 2022-12-04.
  23. ^ "NSF Award Search: Award # 2143419 - CAREER: Shape-Encoded Electrokinetic Particles for Multiplexed Biosensing". www.nsf.gov. Retrieved 2022-12-04.
  24. ^ "College of engineering celebrates 6 NSF CAREER award winners in 2022". College of Engineering & Applied Science. 2022-06-26. Retrieved 2022-12-04.
  25. ^ "2022 Young Investigator Award Recipients". Office of Naval Research. Retrieved 2022-12-04.
  26. ^ "C. Wyatt Shields IV, Ph.D." pew.org. Retrieved 2022-12-04.
  27. ^ "Wyatt Shields named Pew Scholar in Biomedical Sciences". College of Engineering & Applied Science. 2022-06-13. Retrieved 2022-12-04.
  28. ^ "Fellowship Directory". The David and Lucile Packard Foundation. Retrieved 2022-12-04.
  29. ^ "CU Boulder innovators awarded $1.25 million in commercialization funding". Venture Partners at CU Boulder. 2022-11-09. Retrieved 2022-12-04.
  30. ^ "NSF Graduate Research Fellowship and Major External Fellowship Recipients". Duke Pratt School of Engineering. 2016-10-31. Retrieved 2022-12-04.
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