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CYP26A1

From Wikipedia, the free encyclopedia
CYP26A1
Identifiers
AliasesCYP26A1, CP26, CYP26, P450RAI, P450RAI1, cytochrome P450 family 26 subfamily A member 1
External IDsOMIM: 602239; MGI: 1096359; HomoloGene: 37349; GeneCards: CYP26A1; OMA:CYP26A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_057157
NM_000783

NM_007811

RefSeq (protein)

NP_000774
NP_476498

NP_031837

Location (UCSC)Chr 10: 93.07 – 93.08 MbChr 19: 37.69 – 37.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene.[5][6][7]

Function

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.[7]

CYP26A1 is over-expressed in colorectal cancer cells compared to normal colonic epithelium but is of no independent prognostic value in patients with colorectal cancer.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095596Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024987Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M (July 1997). "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450". The Journal of Biological Chemistry. 272 (30): 18538–41. doi:10.1074/jbc.272.30.18538. PMID 9228017.
  6. ^ White JA, Beckett B, Scherer SW, Herbrick JA, Petkovich M (March 1998). "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3". Genomics. 48 (2): 270–2. doi:10.1006/geno.1997.5157. PMID 9521883.
  7. ^ a b "Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1".
  8. ^ Brown GT, Cash BG, Blihoghe D, Johansson P, Alnabulsi A, Murray GI (2014-03-07). "The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer". PLOS ONE. 9 (3): e90776. Bibcode:2014PLoSO...990776B. doi:10.1371/journal.pone.0090776. PMC 3946526. PMID 24608339.
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Further reading

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