Diferric-transferrin reductase
 | This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. (December 2022) |
| diferric-transferrin reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.16.1.2 | ||||||||
| CAS no. | 105238-49-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a diferric-transferrin reductase (EC 1.16.1.2) is an enzyme that catalyzes the chemical reaction
- transferrin[Fe(II)]2 + NAD+ + H+ transferrin[Fe(III)]2 + NADH
The 3 substrates of this enzyme are [[transferrin[Fe(II)]2]], NAD+, and H+, whereas its two products are [[transferrin[Fe(III)]2]] and NADH.
This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is transferrin[Fe(II)]2:NAD+ oxidoreductase. Other names in common use include diferric transferrin reductase, NADH diferric transferrin reductase, and transferrin reductase. This enzyme participates in porphyrin and chlorophyll metabolism.
Structural studies[edit]
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1L5T.
References[edit]
- Low H, Sun IL, Navas P, Grebing C, Crane FL, Morre DJ (1986). "Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system". Biochem. Biophys. Res. Commun. 139 (3): 1117–23. doi:10.1016/S0006-291X(86)80293-5. PMID 3767994.
