Donald Landry

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Donald W. Landry
CitizenshipUnited States
Known forStem cell and artificial enzyme research
SpouseMaureen O'Reilly-Landry
AwardsPresidential Citizens Medal

Donald W. Landry is an American scientist who is the Hamilton Southworth Professor of Medicine, Chair of the Department of Medicine at Columbia University and Physician-in-Chief at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center since 2008. He is also past founding director of the Division of Experimental Therapeutics, and past director of the Division of Nephrology. Landry completed his Ph.D. in organic chemistry with R.B. Woodward at Harvard University in 1979 and then obtained the M.D. degree from Columbia University in 1983. After completing his residency in internal medicine at the Massachusetts General Hospital/Harvard Medical School, he returned to Columbia for training as an NIH Physician-Scientist, 1985–90, and has remained as a member of the Columbia faculty.[1][2]

Personal life[edit]

His wife, Maureen, is a clinical psychologist and psychoanalyst.[3][4] They have two sons.[citation needed]

Work and achievements[edit]

Landry directed the Doris Duke Clinical Research Fellowship Program's Columbia site and co-directed the Advanced Pathophysiology course for 4th-year medical students at the Columbia College of Physicians and Surgeons, both for over a decade.[5] Landry was a member of the President's Council on Bioethics and is co-chair of the Witherspoon Council for Ethics and the Integrity of Science.[1][6] He is a founder of Tonix Pharmaceuticals (NASDAQ: TNXP),[7] a member of the Board of Directors of Sensient Technologies, and chair of the scientific advisory board of Applied Therapeutics, Inc., which was founded based on his patents and now trades on NASDAQ.[8][9] He is co-founder of Tegrigen Therapeutics, a biotech start-up focused on integrin targets.

Landry was elected to membership of the American Society for Clinical Investigation and the Association of American Physicians.[10][11] He is listed in Who's Who in the World and in 2015 was inducted at the Smithsonian as an elected Fellow of the National Academy of Inventors.[12][13] Landry received the Presidential Citizens Medal, the nation's second-highest civilian honor, from President George W. Bush at the Oval Office in 2008 "for diverse and pioneering research and his efforts to improve the well-being of his fellow man."[14]

Research[edit]

Landry has focused on novel approaches to intractable health problems, combining medicine and organic chemistry. His work on cocaine addiction led to the discovery of an artificial enzyme to degrade cocaine. His report on the enzyme, published in Science, was chosen by the American Chemical Society as one of the 25 most important chemistry papers in the world for 1993.[15][16] An agent (Cocaine esterase) he co-developed to treat cocaine overdose has entered clinical trials from Tonix Pharmaceuticals.[17][18][19] He founded the Columbia Organic Chemistry Collaborative Center and it is through this Center that he conducts his current work on drug discovery.[20]

Landry discovered a new hormone deficiency syndrome: vasopressin deficiency in vasodilatory shock. In pioneering the use of vasopressin to treat septic shock and vasodilatory shock after cardiopulmonary bypass, he changed clinical practice for these life-threatening conditions. He also founded ICU nephrology at Columbia, introducing continuous renal replacement therapy to treat renal failure in patients with shock.[21]

Landry developed an alternative method for the production of human embryonic stem cells that relies on harvesting live, normal cells from embryos that—by objective, peer-reviewed criteria—have died of natural causes. Cells harvested from dead embryos would be covered under the established ethics governing transplantation of essential organs from deceased donors.[22]

References[edit]

  1. ^ a b "The President's Council on Bioethics: William B. Hurlbut, M.D." bioethicsarchive.georgetown.edu. Retrieved 2022-03-09.
  2. ^ "Donald W. Landry, MD, Nephrology - at CUIMC/Presbyterian Hospital and Vanderbilt Clinic". doctors.columbia.edu. Retrieved 2022-03-09.
  3. ^ "Maureen O'Reilly-Landry, PhD". columbiapsychiatry.org. 9 February 2017.
  4. ^ "Our Team". Resilience and Covid. Retrieved 2022-03-09.
  5. ^ "Columbia University College Of Physicians & Surgeons Selected To Participate In Doris Duke Clinical Research Fellowship Program". Columbia University Irving Medical Center. 2000-12-15. Retrieved 2022-03-09.
  6. ^ "The Witherspoon Council on Ethics and the Integrity of Science". www.witherspooncouncil.org. Retrieved 2022-03-09.
  7. ^ "Tonix Pharmaceuticals Holding Corp (TNXP) Stock Price & News - Google Finance". www.google.com. Retrieved 2022-10-31.
  8. ^ "SXT Company Profile & Executives - Sensient Technologies Corp. - Wall Street Journal". www.wsj.com. Retrieved 2022-03-09.
  9. ^ "Donald Landry". Applied Therapeutics. Retrieved 2022-03-09.
  10. ^ "The American Society for Clinical Investigation". Archived from the original on 2022-10-18. Retrieved 2022-03-09.
  11. ^ "Association of American Physicians". aap-online.org. Retrieved 2022-03-09.
  12. ^ "National Academy of Inventors". Retrieved 2022-03-09.
  13. ^ Perruso, Alison (2014). Who's Who in the World 2015. Marquis Who's Who. ISBN 978-0837911540.
  14. ^ "Dr. Donald Landry Honored With Presidential Citizens Medal | NYP". www.nyp.org. Retrieved 2022-03-09.
  15. ^ Landry, Donald W. (1993). "Antibody-catalyzed degradation of cocaine". Science. 259 (5103): 1899–1901. Bibcode:1993Sci...259.1899L. doi:10.1126/science.8456315. PMID 8456315.
  16. ^ "Donald Landry Named P&S Chair Of Medicine". Columbia University Irving Medical Center. 2008-11-05. Retrieved 2022-03-09.
  17. ^ "Overdose Research Grant Awarded To Chatham-Based Pharma Company". Chatham, NJ Patch. 2022-07-26. Retrieved 2022-10-31.
  18. ^ "The Prospects for TNX-1300, a Drug to Reverse Cocaine Overamps". Filter. 2022-09-02. Retrieved 2022-10-31.
  19. ^ Tonix Pharmaceuticals, Inc. (2022-06-23). "An Open-Label, Randomized Pilot Study Comparing the Safety of a Single Dose of TNX-1300 to Usual Care (UC) Alone for the Treatment of Signs and Symptoms of Acute Cocaine Intoxication in Male Emergency Department (ED) Subjects". {{cite journal}}: Cite journal requires |journal= (help)
  20. ^ "Organic Chemistry Collaborative Center (OCCC)". Vagelos College of Physicians and Surgeons. 2018-11-28. Retrieved 2022-03-09.
  21. ^ Landry, Donald W. (1997). "Vasopressin deficiency contributes to the vasodilation of septic shock". Circulation. 95 (5): 1122–1125. doi:10.1161/01.CIR.95.5.1122. PMID 9054839.
  22. ^ Landry, Donald W. (2004). "Embryonic death and the creation of human embryonic stem cells". Journal of Clinical Investigation. 114 (9): 1184–1186. doi:10.1172/JCI23065. PMC 524233. PMID 15520846.
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