Draft:Harry Destecroix

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Harry Destecroix
Born10 April 1987
Occupation(s)Entrepreneur, Investor, Scientist
Known forScience Creates, Ziylo, Carbometrics, SCVC

Harry Destecroix (born 10 April 1987) is a British scientist, entrepreneur, and investor. During his PhD in 2014, he co-founded the biotech start-up Ziylo. Harry founded Science Creates in 2017, an organisation supporting the formation of deep tech spinouts. Ziylo was later acquired by Novo Nordisk for up to $800 million.[1][2].

Destecroix co-founded the Science Creates Outreach charity that aims to spark a passion for deep tech entrepreneurship among schoolchildren. Science Creates has established two deep tech incubators in Bristol, with a third in development[3][4], and two UKRI-backed accelerator programs for engineering biology[5][6].

Destecroix is co-founder and Managing Partner of SCVC, a Venture Capital firm that invests in early-stage deep tech start-ups[7]. In 2023 the firm announced the first close of its second fund, aiming for a $100 million target [8][9].

Early life and education[edit]

Destecroix was born in Winchester and attended Bohunt School in Hampshire. He pursued an undergraduate degree in Applied Chemistry at the University of Plymouth and later earned his PhD in the research group of Professor Anthony Davis at the University of Bristol.

Career[edit]

  • 2012: Co-authored a paper on Ziylo's glucose receptor published in Nature Chemistry [10].
  • 2014: Co-founded Ziylo during his PhD studies, focusing on glucose sensing technology.
  • 2015: Co-founded Science Creates, an organisation aiming to support deep tech spinouts and scientific entrepreneurship[11] .
  • 2018: Ziylo was acquired by Novo Nordisk for up to $800 million [12] [13].
  • 2018: Co-founded Carbometrics
  • 2020: Co-founded SCVC, a Venture Capital firm investing in early-stage deep tech startups[7].
  • 2023: Launched Science Creates engineering biology accelerator, supported by UKRI [5].
  • 2023: SCVC won Growth Investor Awards emerging VC of the year [14].
  • 2023: Advised the UK government's review of university spin-out companies [15] [16].
  • 2024: Launched Science Creates second engineering biology accelerator [17].

Inspiration and Motivation[edit]

While building Ziylo, Harry found there was a lack of lab space and support for university science spinouts in the West of England [18]. This inspired him to establish an incubator to provide infrastructure and tailored support for scientific companies, a resource that was lacking during his own ventures [19].

Harry believes that progress in improving health and addressing climate change will stem from fundamental discoveries made at universities. However, he notes that the commercialisation process often hinders these discoveries from achieving their full impact [20][19].

Challenges in securing funding for Ziylo also motivated Harry to build a Venture Capital specialising in early-stage deep tech spinouts and startups [19][8]. In a Chemistry World article, he emphasised the need for more scientists and successful company founders to enter VC, along with the development of venture ecosystems around universities and the necessary infrastructure [19].

Public and Political Activities[edit]

Destecroix advised the UK Government's Independent Review of University Spin-out Companies in November 2023 [15] [16]. The UK Government funding agency for innovation, UKRI, has backed two Science Creates accelerator programs for engineering biology[5].

Publications[edit]

  • A simple and accessible synthetic lectin for glucose recognition and sensing. Nature Chemistry. 2012 [10].
  • Near-Infrared Croconaine Rotaxanes and Doped Nanoparticles for Enhanced Aqueous Photothermal Heating. Chemistry. 2014 [21].
  • Affinity Enhancement by Dendritic Side Chains in Synthetic Carbohydrate Receptors. Angewandte Chemie International Edition. 2015 [22].
  • Rapid Macrocycle Threading by a Fluorescent Dye–Polymer Conjugate in Water with Nanomolar Affinity. Journal of the American Chemical Society. 2015. [23].
  • Crystal structure of a complex between β-glucopyranose and a macrocyclic receptor with dendritic multicharged water solubilizing chains. Chemical Communications. 2016 [24].

Awards[edit]

  • OBN Award for Best Sector Support Organisation 2018 [25].
  • Alumni Award for Innovation and Enterprise 2019 [26].
  • UKBAA Angel Investment Awards - Exit of the Year 2019 [27].
  • Barclays Entrepreneur Awards - National Icon of the Year 2023 [28].
  • Chemistry World - Entrepreneur of the Year 2023 [29]

References[edit]

  1. ^ Milne, Gemma. "Bristol Diabetes Spin-Out Acquired By Novo Nordisk For $800M". Forbes. Retrieved 2024-01-30.
  2. ^ Owens, Brian (2018-11-01). "Smart insulin: redesign could end hypoglycemia risk". Nature Biotechnology. 36 (10): 911–912. doi:10.1038/nbt1018-911a. ISSN 1546-1696. PMID 30307920. S2CID 52955049.
  3. ^ Bristol, University of. "November: science-creates | News and features | University of Bristol". www.bristol.ac.uk. Retrieved 2024-01-31.
  4. ^ "Deal for £8.5m 'deep tech' building at University of Bristol". www.bbc.com. Retrieved 2024-01-31.
  5. ^ a b c "UKRI and Science Creates launch engineering biology accelerator". www.ukri.org. 2023-06-22. Retrieved 2024-01-31.
  6. ^ "UKRI and Science Creates launch engineering biology accelerator". www.ukri.org. 2023-06-22. Retrieved 2024-03-15.
  7. ^ a b Butcher, Mike (2020-12-08). "Bristol entrepreneur who exited for up to $800M doubles-down on the city with deep-tech incubator and VC fund". TechCrunch. Retrieved 2024-01-31.
  8. ^ a b Butcher, Mike (2023-09-14). "UK deep tech gets another boost with new $100M SCVC fund out of Bristol". TechCrunch. Retrieved 2024-01-31.
  9. ^ Cook, James (2023-09-14). "First close completed for SCVC's latest $100m deep tech fund - Business Leader News". Business Leader. Retrieved 2024-01-31.
  10. ^ a b Ke, Chenfeng; Destecroix, Harry; Crump, Matthew P.; Davis, Anthony P. (2012). "A simple and accessible synthetic lectin for glucose recognition and sensing". Nature Chemistry. 4 (9): 718–723. Bibcode:2012NatCh...4..718K. doi:10.1038/nchem.1409. hdl:1983/7639a4a5-0aa8-44aa-bf18-8bd46572c2cb. ISSN 1755-4349. PMID 22914192. S2CID 1926457.
  11. ^ Extance2016-11-22T14:32:00+00:00, Andy. "Chemist's struggles spawn Bristol lab incubator". Chemistry World. Retrieved 2024-01-31.{{cite web}}: CS1 maint: numeric names: authors list (link)
  12. ^ Novo Nordisk (17 August 2018). "Novo Nordisk acquires Ziylo Ltd to accelerate its development of glucose responsive insulins" (PDF).
  13. ^ Bristol, University of. "August: University spin-out Ziylo acquired by global healthcare company | News and features | University of Bristol". www.bristol.ac.uk. Retrieved 2024-01-31.
  14. ^ "Winners 2022 | Growth Investor Awards". growthinvestorawards.com. Retrieved 2024-01-31.
  15. ^ a b "A Spin-Out founder story and the UK's Spin-Out review". www.linkedin.com. Retrieved 2024-01-31.
  16. ^ a b "Independent review of university spin-out companies". GOV.UK. 2023-11-22. Retrieved 2024-01-31.
  17. ^ "UKRI and Science Creates launch engineering biology accelerator". www.ukri.org. 2023-06-22. Retrieved 2024-03-15.
  18. ^ "dx19 by Unit DX by Unit DX - Issuu". issuu.com. 2019-06-26. Retrieved 2024-01-31.
  19. ^ a b c d "Building the support infrastructure we wish we'd had". Chemistry World. Retrieved 2024-01-31.
  20. ^ Science Creates (2020). "From Discoveries to Inventions. Science Creates Launch Paper 2020" (PDF).
  21. ^ Spence, Graeme T.; Lo, Shun Shang; Ke, Chenfeng; Destecroix, Harry; Davis, Anthony P.; Hartland, Gregory V.; Smith, Bradley D. (2014-09-22). "Near-infrared croconaine rotaxanes and doped nanoparticles for enhanced aqueous photothermal heating". Chemistry (Weinheim an der Bergstrasse, Germany). 20 (39): 12628–12635. doi:10.1002/chem.201403315. ISSN 1521-3765. PMID 25146580.
  22. ^ Destecroix, Harry; Renney, Charles M.; Mooibroek, Tiddo J.; Carter, Tom S.; Stewart, Patrick F. N.; Crump, Matthew P.; Davis, Anthony P. (2015-02-09). "Affinity Enhancement by Dendritic Side Chains in Synthetic Carbohydrate Receptors". Angewandte Chemie International Edition. 54 (7): 2057–2061. doi:10.1002/anie.201409124. ISSN 1433-7851. PMC 4506558. PMID 25645064.
  23. ^ Peck, Evan M.; Liu, Wenqi; Spence, Graeme T.; Shaw, Scott K.; Davis, Anthony P.; Destecroix, Harry; Smith, Bradley D. (2015-07-15). "Rapid Macrocycle Threading by a Fluorescent Dye–Polymer Conjugate in Water with Nanomolar Affinity". Journal of the American Chemical Society. 137 (27): 8668–8671. doi:10.1021/jacs.5b03573. ISSN 0002-7863. PMC 4643739. PMID 26106948.
  24. ^ Mandal, Pradeep K.; Kauffmann, Brice; Destecroix, Harry; Ferrand, Yann; Davis, Anthony P.; Huc, Ivan (2016-07-19). "Crystal structure of a complex between β-glucopyranose and a macrocyclic receptor with dendritic multicharged water solubilizing chains". Chemical Communications. 52 (60): 9355–9358. doi:10.1039/C6CC04466B. ISSN 1364-548X. PMID 27373805. S2CID 206006699.
  25. ^ "UnitDx win 2018 OBN Award for Best Sector Support Organisation | UKSPA". Retrieved 2024-01-31.
  26. ^ Bristol, University of. "2019 Alumni Award winners". www.bristol.ac.uk. Retrieved 2024-01-31.
  27. ^ UKBAA (2021-03-19). "Harry Destecroix, winner of Exit of the Year at the 2019 UKBAA Angel Investment Awards, discusses the importance of being recognised by the awards". UK Business Angels Association. Retrieved 2024-01-31.
  28. ^ "Entrepreneur Awards Hall of Fame | Barclays". www.barclays.co.uk. Retrieved 2024-01-31.
  29. ^ "Dr Harry Destecroix - 2023 Chemistry World Entrepreneur of the Year winner". Royal Society of Chemistry. Retrieved 2024-01-31.