EVI5

EVI5
Identifiers
Aliases	EVI5, NB4S, EVI-5, ecotropic viral integration site 5
External IDs	OMIM: 602942 MGI: 104736 HomoloGene: 121902 GeneCards: EVI5
Gene location (Human) Chr. Chromosome 1 (human) Band 1p22.1 Start 92,508,696 bp End 92,792,404 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 52.23 cM Start 107,892,661 bp End 108,022,973 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve seminal vesicula parietal pleura corpus callosum visceral pleura internal globus pallidus germinal epithelium placenta bronchial epithelial cell Top expressed in sciatic nerve secondary oocyte saccule facial motor nucleus left lobe of liver cumulus cell utricle otic placode optic nerve median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm cytosol spindle cytoskeleton nucleus microtubule organizing center endomembrane system Golgi apparatus intracellular membrane-bounded organelle Biological process cell division multicellular organism development regulation of cilium assembly regulation of GTPase activity cell cycle cell population proliferation retrograde transport, endosome to Golgi regulation of vesicle fusion intracellular protein transport activation of GTPase activity positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7813 14020 Ensembl ENSG00000067208 ENSMUSG00000011831 UniProt O60447 P97366 RefSeq (mRNA) NM_001308248 NM_005665 NM_001350197 NM_001350198 NM_001377210 NM_001377211 NM_001377212 NM_001377213 NM_007964 NM_001378824 NM_001378825 RefSeq (protein) NP_001295177 NP_005656 NP_001337126 NP_001337127 NP_001364139 NP_001364140 NP_001364141 NP_001364142 n/a Location (UCSC) Chr 1: 92.51 – 92.79 Mb Chr 5: 107.89 – 108.02 Mb PubMed search
Wikidata
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Ecotropic viral integration site 5 protein homolog is a protein that in humans is encoded by the EVI5 gene.

Further reading

• Dabbeekeh JT, Faitar SL, Dufresne CP, Cowell JK (Apr 2007). "The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11". Oncogene. 26 (19): 2804–8. doi:10.1038/sj.onc.1210081. PMID 17099728.
• Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG (Jan 2007). "Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene". Proceedings of the National Academy of Sciences of the United States of America. 104 (4): 1236–41. Bibcode:2007PNAS..104.1236W. doi:10.1073/pnas.0610500104. PMC 1773056. PMID 17229837.
• Faitar SL, Sossey-Alaoui K, Ranalli TA, Cowell JK (Jul 2006). "EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis". Experimental Cell Research. 312 (12): 2325–35. doi:10.1016/j.yexcr.2006.03.032. PMID 16764853.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK (Jan 2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell. 124 (2): 367–80. doi:10.1016/j.cell.2005.10.038. PMID 16439210. S2CID 15578836.
• Faitar SL, Dabbeekeh JT, Ranalli TA, Cowell JK (Nov 2005). "EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin". Genomics. 86 (5): 594–605. doi:10.1016/j.ygeno.2005.06.002. PMID 16033705.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.