Enah/Vasp-like

EVL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QC6
Identifiers
Aliases	EVL, RNB6, Enah/Vasp-like
External IDs	OMIM: 616912 MGI: 1194884 HomoloGene: 56752 GeneCards: EVL
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.2 Start 99,971,449 bp End 100,144,236 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 F1 Start 108,520,979 bp End 108,654,775 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence lymph node nucleus accumbens prefrontal cortex anterior pituitary caudate nucleus spleen Brodmann area 9 amygdala putamen Top expressed in dorsomedial hypothalamic nucleus ganglionic eminence molar lateral hypothalamus habenula dorsal tegmental nucleus olfactory bulb superior cervical ganglion mammillary body medial dorsal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function profilin binding SH3 domain binding protein binding actin binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion cytoskeleton lamellipodium phagocytic vesicle Biological process positive regulation of actin filament polymerization negative regulation of ruffle assembly actin filament organization nervous system development axon guidance cell surface receptor signaling pathway animal organ morphogenesis actin polymerization or depolymerization protein homotetramerization negative regulation of epithelial cell migration positive regulation of stress fiber assembly actin nucleation cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51466 14026 Ensembl ENSG00000196405 ENSMUSG00000021262 UniProt Q9UI08 P70429 RefSeq (mRNA) NM_016337 NM_001330221 NM_001163394 NM_001163395 NM_001163396 NM_007965 RefSeq (protein) NP_001317150 NP_057421 NP_001156866 NP_001156867 NP_001156868 NP_031991 Location (UCSC) Chr 14: 99.97 – 100.14 Mb Chr 12: 108.52 – 108.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Ohta S, Mineta T, Kimoto M, Tabuchi K (1997). "Differential display cloning of a novel rat cDNA (RNB6) that shows high expression in the neonatal brain revealed a member of Ena/VASP family". Biochem. Biophys. Res. Commun. 237 (2): 307–12. doi:10.1006/bbrc.1997.7113. PMID 9268706.
• Krause M, Sechi AS, Konradt M, et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Dev. Cell. 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
• Lafuente EM, van Puijenbroek AA, Krause M, et al. (2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell. 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. hdl:1721.1/83508. PMID 15469846.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rotter B, Bournier O, Nicolas G, et al. (2005). "AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts". Biochem. J. 388 (Pt 2): 631–8. doi:10.1042/BJ20041502. PMC 1138971. PMID 15656790.
• Barzik M, Kotova TI, Higgs HN, et al. (2005). "Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins". J. Biol. Chem. 280 (31): 28653–62. doi:10.1074/jbc.M503957200. PMC 1747414. PMID 15939738.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Bournier O, Kroviarski Y, Rotter B, et al. (2006). "Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization". Biol. Cell. 98 (5): 279–93. doi:10.1042/BC20050024. PMID 16336193.
• Bausen M, Fuhrmann JC, Betz H, O'sullivan GA (2006). "The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members". Mol. Cell. Neurosci. 31 (2): 376–86. doi:10.1016/j.mcn.2005.11.004. PMID 16376568. S2CID 24824029.