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Epoetin beta

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Epoetin beta
Clinical data
Pronunciation/ɛˈp.ɪtɪn/
Trade namesNeorecormon, Betapoietin, others[1]
AHFS/Drugs.comInternational Drug Names
License data
Pregnancy
category
Routes of
administration
Intravenous, subcutaneous
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)[2]
  • EU: Rx-only[3]
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
 ☒NcheckY (what is this?)  (verify)

Epoetin beta (INN), sold under the brand name Neorecormon among others, is a synthetic, recombinant[4] form of erythropoietin, a protein that promotes the production of red blood cells. It is an erythropoiesis-stimulating agent (ESA) that is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy.

It is on the World Health Organization's List of Essential Medicines.[5]

Chemistry

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Epoetin beta is a recombinant form of human erythropoietin which is produced in Chinese hamster ovary cells. It has the same protein sequence as natural human erythropoietin, being composed of 165 amino acids with about 30 KDa molecular weight.[6]

History

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Erythropoietin (EPO) is a hormone produced in the kidneys. The existence of this hormone has been known since 1906, when scientists first started isolating it, and since the 1980s, a recombinant version of the hormone has been available for use in medical treatment.[citation needed]

See also

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References

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  1. ^ Centers for Medicare and Medicaid Services: Erythrocyte Stimulating Agents Archived 2017-06-07 at the Wayback Machine. Retrieved 15 February 2017.
  2. ^ a b Australian product information Archived 2023-01-09 at the Wayback Machine guildlink.com.au
  3. ^ "NeoRecormon EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 January 2023. Retrieved 9 January 2023.
  4. ^ Dunn CJ, Markham A (February 1996). "Epoetin beta. A review of its pharmacological properties and clinical use in the management of anaemia associated with chronic renal failure". Drugs. 51 (2): 299–318. doi:10.2165/00003495-199651020-00008. PMID 8808169. S2CID 46985336.
  5. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  6. ^ Medsafe: Neorecormon Datasheet Archived 2020-08-30 at the Wayback Machine

Further reading

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[edit]
  • "Epoetin beta". Drug Information Portal. U.S. National Library of Medicine.