FCRLA

FCRLA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HWN
Identifiers
Aliases	FCRLA, FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB, Fc receptor like A
External IDs	OMIM: 606891 MGI: 2138647 HomoloGene: 13106 GeneCards: FCRLA
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,714,352 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,755,152 bp
RNA expression pattern
	Top expressed in
	lymph node; ; spleen; ; appendix; ; superficial temporal artery; ; pancreatic ductal cell; ; bone marrow cells; ; blood; ; thymus; ; trabecular bone; ; rectum;
	Top expressed in
	spleen; ; blood; ; spermatocyte; ; bone marrow; ; subcutaneous adipose tissue; ; thymus; ; spermatid; ; left colon; ; seminiferous tubule; ; jejunum;
	More reference expression data
	n/a
Orthologs
	84824
	98752
	ENSG00000132185
	ENSMUSG00000038421
	Q7L513
	Q920A9
NM_001184866; NM_001184867; NM_001184870; NM_001184871; NM_001184872;
	NM_001184873; NM_032738; NM_001366195; NM_001366196
	NM_001160215; NM_145141
NP_001171795; NP_001171796; NP_001171799; NP_001171800; NP_001171801;
	NP_001171802; NP_116127; NP_001353124; NP_001353125
	NP_001153687; NP_660123
	Wikidata
View/Edit Human	View/Edit Mouse

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.^[5]^[6]

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132185 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038421 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol. 32 (1): 87–96. doi:10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-#. PMID 11754007. S2CID 196599868.
^ ^a ^b "Entrez Gene: FCRLA Fc receptor-like A".

Further reading[edit]

Facchetti F, Cella M, Festa S, et al. (2002). "An unusual Fc receptor-related protein expressed in human centroblasts". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3776–81. Bibcode:2002PNAS...99.3776F. doi:10.1073/pnas.022042699. PMC 122600. PMID 11891275.
Davis RS, Li H, Chen CC, et al. (2003). "Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells". Int. Immunol. 14 (9): 1075–83. doi:10.1093/intimm/dxf074. PMID 12202404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Huizinga TW, Ioan-Facsinay A (2004). "Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways". J. Rheumatol. 30 (9): 1904–6. PMID 12966588.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Inozume T, Matsuzaki Y, Kurihara S, et al. (2005). "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients". Int. J. Cancer. 114 (2): 283–90. doi:10.1002/ijc.20735. PMID 15551350.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841. S2CID 1971426.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132185 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038421 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11754007-5] Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol. 32 (1): 87–96. doi:10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-#. PMID 11754007. S2CID 196599868.

[entrez-6] "Entrez Gene: FCRLA Fc receptor-like A".

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