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Protein-coding gene in the species Homo sapiens
HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene .
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Function [ edit ]
This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis . Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis .
Poly (ADP-ribosylation ) of the encoded protein promotes its translocation to centrosomes , which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.
References [ edit ]
Further reading [ edit ]
This article incorporates text from the United States National Library of Medicine , which is in the public domain .