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HIVEP1

From Wikipedia, the free encyclopedia
HIVEP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHIVEP1, CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A, human immunodeficiency virus type I enhancer binding protein 1, HIVEP zinc finger 1
External IDsOMIM: 194540; MGI: 96100; HomoloGene: 1596; GeneCards: HIVEP1; OMA:HIVEP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002114

NM_007772

RefSeq (protein)

NP_002105

NP_031798

Location (UCSC)Chr 6: 12.01 – 12.16 MbChr 13: 42.21 – 42.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.[5][6]

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095951Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021366Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ (Jul 1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24". Genomics. 9 (4): 758–61. doi:10.1016/0888-7543(91)90371-K. PMID 2037300.
  6. ^ a b "Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.