Hanoch Senderowitz

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Hanoch Senderowitz
Born1963
Tel Aviv, Israel
CitizenshipIsraeli
Alma materTel Aviv University
Scientific career
FieldsComputational Chemistry, Molecular modelling, Computer-Aided Drug Design, Chemoinformatics, Materials informatics
InstitutionsBar-Ilan University
Doctoral advisorBenzion Fuchs
Other academic advisorsW. Clark Still (Columbia University)

Hanoch Senderowitz (born 1963) (Hebrew: חנוך סנדרוביץ) is an Israeli chemist specializing in the fields of Computational Chemistry, Molecular modelling, Computer-Aided Drug Design, and Chemoinformatics.[1][2]

Biography[edit]

Hanoch Senderowitz received his Ph.D. in 1993 from Tel Aviv University under the supervision of Prof. Benzion Fuchs. He then spent four years as a Post Doctorate Fulbright fellow at Columbia University, working with Prof. W. Clark Still. After returning to Israel in 1997, he joined the pharmaceutical industry, working first at Peptor Ltd. for six years and then at Epix Pharmaceuticals until 2008.[1][2] In 2009, he joined Bar Ilan University as an associate professor at the Department of Chemistry leading the molecular modeling, computer-aided drug design and chemoinformatics lab.[1]

Scientific interests and publications[edit]

Senderowitz's research focuses on the developing and application of new computational methods to design compounds (i.e., drugs, materials) with improved properties. This design strategy is multi-disciplinary in nature and consists of various levels of theory, different computational techniques, and different machine learning algorithms. Senderowitz is known for the following areas of research: (1) Research on CFTR (Cystic fibrosis transmembrane conductance regulator), the main protein implicated in the genetic disease Cystic fibrosis, both at the level of the full-length protein[3][4][5] and of its domains.[6][7] His basic research focuses on understanding the dynamics of the protein and on the mechanism of action of deleterious, rescuing and stabilizing perturbations to its domains, while his translation research focuses on CFTR as a target for drug discovery. (2) Research on chemoinformatics and materials informatics, focusing on the development of new machine learning algorithms[8][9][10][11] as well as on their application in various areas, for example, for the analysis and development of solar cells with improved photovoltaic properties.[12][13][14][15] (3) Research on computational agriculture including plant disease biocontrol studying anti-bacterial peptides expressed on virus nanoparticles, design of new pesticides in the form of small molecules that inhibits the bacterial quorum sensing machinery, and the design of new sustainable pesticides in the form of peptide aptamers and small molecules that would interfere with cell building enzymes of bacteria.[16] (4) Research on different drug discovery projects, in particular in the field of neurodegenerative diseases such as ALS, Alzheimer, familial dysautonomia and the vanishing white material disease[17] as well as diabetes,[18] and calcification-related diseases and autoimmune disease.[19][20][21]

He has over 90 peer-reviewed articles, and has contributed to various book chapters.[22][23][24][25]

References[edit]

  1. ^ a b c Hanoch Senderowitz, Department of Chemistry, Bar-Ilan University
  2. ^ a b Hanoch Senderowitz, Research Authority, Bar-Ilan University
  3. ^ Mei-Zahav, M.; Stafler, P.; Senderowitz, H.; Bentur, L.; Livnat, G.; Shteinberg, M.; Orenstein, N.; Bazak, L.; Prais, D.; Levine, H.; Gur, M.; Khazanov, N.; Simhaev, L.; Eliyahu, H.; Cohen, M.; Wilschanski, M.; Blau, H.; Mussaffi, H. (2018). "The Q359K/T360K mutation causes cystic fibrosis in Georgian Jews". Journal of Cystic Fibrosis. 17 (5): e41–e45. doi:10.1016/j.jcf.2018.06.008. ISSN 1569-1993. PMID 30033373.
  4. ^ Simhaev, Luba; McCarty, Nael A.; Ford, Robert C.; Senderowitz, Hanoch (2017). "Molecular Dynamics Flexible Fitting Simulations Identify New Models of the Closed State of the Cystic Fibrosis Transmembrane Conductance Regulator Protein". Journal of Chemical Information and Modeling. 57 (8): 1932–1946. doi:10.1021/acs.jcim.7b00091. ISSN 1549-9596. PMID 28657312.
  5. ^ Thibodeau, Patrick H.; Richardson, John M.; Wang, Wei; Millen, Linda; Watson, Jarod; Mendoza, Juan L.; Du, Kai; Fischman, Sharon; Senderowitz, Hanoch; Lukacs, Gergely L.; Kirk, Kevin; Thomas, Philip J. (2010). "The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis". Journal of Biological Chemistry. 285 (46): 35825–35835. doi:10.1074/jbc.M110.131623. ISSN 0021-9258. PMC 2975206. PMID 20667826.
  6. ^ Chen, Xinying; Zhu, Siyu; Zhenin, Michael; Xu, Weiyi; Bose, Samuel J.; Wong, Molly Pik-Fan; Leung, George P. H.; Senderowitz, Hanoch; Chen, Jeng-Haur (2019). "A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis–causing mutation" (PDF). The FASEB Journal. 33 (4): 5126–5142. doi:10.1096/fj.201801218RR. ISSN 0892-6638. PMID 30668920.
  7. ^ Zhenin, Michael; Noy, Efrat; Senderowitz, Hanoch (2015). "REMD Simulations Reveal the Dynamic Profile and Mechanism of Action of Deleterious, Rescuing, and Stabilizing Perturbations to NBD1 from CFTR". Journal of Chemical Information and Modeling. 55 (11): 2349–2364. doi:10.1021/acs.jcim.5b00312. ISSN 1549-9596. PMID 26418372.
  8. ^ Kaspi, Omer; Yosipof, Abraham; Senderowitz, Hanoch (2017). "RANdom SAmple Consensus (RANSAC) algorithm for material-informatics: application to photovoltaic solar cells". Journal of Cheminformatics. 9 (1): 34. doi:10.1186/s13321-017-0224-0. ISSN 1758-2946. PMC 5461245. PMID 29086047.
  9. ^ Nahum, Oren E.; Yosipof, Abraham; Senderowitz, Hanoch (2015). "A Multi-Objective Genetic Algorithm for Outlier Removal". Journal of Chemical Information and Modeling. 55 (12): 2507–2518. doi:10.1021/acs.jcim.5b00515. ISSN 1549-9596. PMID 26553402.
  10. ^ Yosipof, Abraham; Senderowitz, Hanoch (2015). "k-Nearest neighbors optimization-based outlier removal". Journal of Computational Chemistry. 36 (8): 493–506. doi:10.1002/jcc.23803. ISSN 0192-8651. PMID 25503870. S2CID 7086146.
  11. ^ Yosipof, Abraham; Senderowitz, Hanoch (2014). "Optimization of Molecular Representativeness". Journal of Chemical Information and Modeling. 54 (6): 1567–1577. doi:10.1021/ci400715n. ISSN 1549-9596. PMID 24802762.
  12. ^ Kaspi, Omer; Yosipof, Abraham; Senderowitz, Hanoch (2018). "Visualization of Solar Cell Library Space by Dimensionality Reduction Methods". Journal of Chemical Information and Modeling. 58 (12): 2428–2439. doi:10.1021/acs.jcim.8b00552. ISSN 1549-9596. PMID 30485100. S2CID 54102900.
  13. ^ Kaspi, Omer; Yosipof, Abraham; Senderowitz, Hanoch (2018). "PV Analyzer: A Decision Support System for Photovoltaic Solar Cells Libraries". Molecular Informatics. 37 (9–10): 1800067. doi:10.1002/minf.201800067. ISSN 1868-1743. PMID 30022619. S2CID 51696788.
  14. ^ Yosipof, Abraham; Shimanovich, Klimentiy; Senderowitz, Hanoch (2016). "Materials Informatics: Statistical Modeling in Material Science". Molecular Informatics. 35 (11–12): 568–579. doi:10.1002/minf.201600047. ISSN 1868-1743. PMID 27870246. S2CID 38316656.
  15. ^ Yosipof, Abraham; Nahum, Oren E.; Anderson, Assaf Y.; Barad, Hannah-Noa; Zaban, Arie; Senderowitz, Hanoch (2015). "Data Mining and Machine Learning Tools for Combinatorial Material Science of All-Oxide Photovoltaic Cells". Molecular Informatics. 34 (6–7): 367–379. doi:10.1002/minf.201400174. ISSN 1868-1743. PMID 27490383. S2CID 3985537.
  16. ^ Joshi, Janak Raj; Khazanov, Netaly; Senderowitz, Hanoch; Burdman, Saul; Lipsky, Alexander; Yedidia, Iris (2016). "Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins". Scientific Reports. 6 (1): 38126. Bibcode:2016NatSR...638126J. doi:10.1038/srep38126. ISSN 2045-2322. PMC 5131480. PMID 27905512.
  17. ^ Atzmon, Andrea; Herrero, Melisa; Sharet-Eshed, Reut; Gilad, Yocheved; Senderowitz, Hanoch; Elroy-Stein, Orna (2018). "Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy". Frontiers in Molecular Neuroscience. 11: 336. doi:10.3389/fnmol.2018.00336. ISSN 1662-5099. PMC 6153319. PMID 30279648.
  18. ^ Munder, Anna; Israel, Liron L.; Kahremany, Shirin; Ben-Shabat-Binyamini, Rina; Zhang, Charles; Kolitz-Domb, Michal; Viskind, Olga; Levine, Anna; Senderowitz, Hanoch; Chessler, Steven; Lellouche, Jean-Paul; Gruzman, Arie (2017). "Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy". ACS Applied Materials & Interfaces. 9 (2): 1189–1206. doi:10.1021/acsami.6b10568. ISSN 1944-8244. PMC 6035049. PMID 28045486.
  19. ^ Getter, Tamar; Margalit, Raanan; Kahremany, Shirin; Levy, Laura; Blum, Eliav; Khazanov, Netaly; Keshet-Levy, Nimrod Y.; Tamir, Tigist Y.; Ben Major, M.; Lahav, Ron; Zilber, Sofia; Senderowitz, Hanoch; Bradfield, Paul; Imhof, Beat A.; Alpert, Evgenia; Gruzman, Arie (2019). "Novel inhibitors of leukocyte transendothelial migration". Bioorganic Chemistry. 92: 103250. doi:10.1016/j.bioorg.2019.103250. ISSN 0045-2068. PMID 31580982. S2CID 203374442.
  20. ^ Trifonov, Lena; Nudelman, Vadim; Zhenin, Michael; Matsree, Erez; Afri, Michal; Schmerling, Bruria; Cohen, Guy; Jozwiak, Krzysztof; Weitman, Michal; Korshin, Edward; Senderowitz, Hanoch; Shainberg, Asher; Hochhauser, Edith; Gruzman, Arie (2018). "Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model". Journal of Medicinal Chemistry. 61 (24): 11309–11326. doi:10.1021/acs.jmedchem.8b01471. ISSN 0022-2623. PMID 30507195. S2CID 54562681.
  21. ^ Zelikman, Vadim; Pelletier, Julie; Simhaev, Luba; Sela, Aviad; Gendron, Fernand-Pierre; Arguin, Guillaume; Senderowitz, Hanoch; Sévigny, Jean; Fischer, Bilha (2018). "Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5′-Pα,α-Dithiophosphate Analogues". Journal of Medicinal Chemistry. 61 (9): 3939–3951. doi:10.1021/acs.jmedchem.7b01906. ISSN 0022-2623. PMID 29681152.
  22. ^ Momic, Tatjana; Katzehendler, Jehoshua; Noy, Efrat; Senderowitz, Hanoch; A. Eble, Johannes; Marcinkiewicz, Cezary; Lazarovici, Philip (2016). "Disintegrin-Based, Synthetic Cyclic KTS Peptides as Novel Dual Antagonists of α1β1/α2β1 Integrins with Antiangiogenic Activity". In Momic, Tatjana; Katzehendler, Jehoshua; Noy, Efrat; Senderowitz, Hanoch; a. Eble, Johannes; Marcinkiewicz, Cezary; Lazarovici, Philip (eds.). Anti-Angiogenesis Drug Discovery and Development. pp. 16–45. doi:10.2174/9781681081557116030004. ISBN 9781681081557.
  23. ^ Yosipof, Abraham; Senderowitz, Hanoch (2016). "Optimization Algorithms for Chemoinformatics and Material-informatics". Optimization Algorithms - Methods and Applications. doi:10.5772/62483. ISBN 978-953-51-2592-1.
  24. ^ Arup Ghose; Vellerkad Viswanadhan (26 June 2001). Combinatorial Library Design and Evaluation: Principles, Software, Tools, and Applications in Drug Discovery. CRC Press. ISBN 978-0-8247-0487-2.
  25. ^ Patai, Saul (1996). The chemistry of amino, nitroso, nitro, and related groups. Chichester England New York: Wiley. ISBN 978-0-471-95171-1.
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