Jane M. Carlton

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Jane M. Carlton is a biologist at New York University whose research centers on the genomics of two groups of single-celled parasites: those which cause malaria (the genus Plasmodium), and trichomonads, which include the common sexually transmitted parasite Trichomonas vaginalis.

Education[edit]

Carlton received her Ph.D. in genetics at the University of Edinburgh, Scotland,[1] and has worked at several scientific institutions in the U.S., including the National Center for Biotechnology Information at the National Institutes of Health and the Institute for Genomic Research (TIGR).

Research[edit]

Carlton is among a group of scientists recording and categorizing changes in all of the malaria parasite's genes at once, with a view toward detecting drug resistance in its earliest stages while it can still be controlled, finding new vulnerabilities in the parasite's genome that can be exploited to fight malaria.[2] As Faculty Director of Genomic Sequencing at NYU's Center for Genomics and Systems Biology, Carlton is examining the genomes of dozens of malaria isolates at a time. Recently her group sequenced several genomes from both a human malaria species (Plasmodium vivax)[3] and a closely related monkey malaria parasite (Plasmodium cynomolgi),[4] producing a more detailed picture of malaria evolution and uncovering a surprising amount of genetic variation in the latter.

Carlton collaborates with scientists at National Institute of Malaria Research in India to develop new research paths and control strategies for the disease there. As Program Director of a seven-year NIH International Center of Excellence in Malaria Research based jointly in New Delhi and NYU, she heads the first pan-Indian genomic survey of malaria parasite strains, along with an in-depth epidemiological study of how the malaria is transmitted and manifests itself in different ecologies and societies in India.[5]

Trichomonads are single-celled parasites that infect humans and other mammals as well as birds. One such parasite is Trichomonas vaginalis, which causes the most widespread non-viral human STD). Carlton led the group that sequenced the genome of Trichomonas vaginalis in 2007 – the first sequencing of any trichomonad genome – and uncovered families of genes that may be responsible for the membrane irritation and damage associated with trichomoniasis.[6][7] The sequencing project also revealed that the parasite's genome is surprisingly large and composed mostly of highly repetitive ‘mobile’ DNA elements.

Awards and honors[edit]

Carlton has published more than 139 research articles and reviews.[8]

She was the recipient of the Stoll-Stunkard Memorial Lectureship Award from the American Society of Parasitologists in 2010.[9][10]

She was elected a Fellow of the American Association for the Advancement of Science in 2012.[11]

References[edit]

  1. ^ "Jane Carlton | World Science Festival". World Science Festival. Retrieved 2018-03-25.
  2. ^ "Malaria Vaccine to be Reality soon". Only My Health. Retrieved 2012-08-08.
  3. ^ Neafsey DE, Galinsky K, Jiang RH, Young L, Sykes SM, Saif S, Gujja S, Goldberg JM, Young S, Zeng Q, Chapman SB, Dash AP, Anvikar AR, Sutton PL, Birren BW, Escalante AA, Barnwell JW, Carlton JM. The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nat Genetics. 2012 Sep;44(9):1046-50.
  4. ^ Tachibana S, Sullivan SA, Kawai S, Nakamura S, Kim HR, Goto N, Arisue N, Palacpac NM, Honma H, Yagi M, Tougan T, Katakai Y, Kaneko O, Mita T, Kita K, Yasutomi Y, Sutton PL, Shakhbatyan R, Horii T, Yasunaga T, Barnwell JW, Escalante AA, Carlton JM, Tanabe K. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nat Genetics. 2012 Aug 5;44(9):1051-5.
  5. ^ "NIH Funds Seven International Centers of Excellence for Malaria Research | News Release". National Institutes of Health. Retrieved 2017-04-21.
  6. ^ "Scientists Sequence Genome of Parasite Responsible for Common Sexually Transmitted Infection | News Release". National Institutes of Health. Retrieved 2007-01-11.
  7. ^ Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, Wortman JR,Bidwell SL, Alsmark UC, Besteiro S, Sicheritz-Ponten T, Noel CJ, Dacks JB, Foster PG, Simillion C, Van de Peer Y, Miranda-Saavedra D, Barton GJ, Westrop GD, Müller S, Dessi D, Fiori PL, Ren Q, Paulsen I, Zhang H, Bastida-Corcuera FD, Simoes-Barbosa A, Brown MT, Hayes RD, Mukherjee M, Okumura CY, Schneider R, Smith AJ, Vanacova S, Villalvazo M, Haas BJ, Pertea M, Feldblyum TV, Utterback TR, Shu CL, Osoegawa K, de Jong PJ, Hrdy I, Horvathova L, Zubacova Z, Dolezal P, Malik SB, Logsdon JM Jr, Henze K, Gupta A, Wang CC, Dunne RL, Upcroft JA, Upcroft P, White O, Salzberg SL, Tang P, Chiu CH, Lee YS, Embley TM, Coombs GH, Mottram JC, Tachezy J, Fraser-Liggett CM, Johnson PJ. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12; 315(5809):207-12.
  8. ^ "Jane M. Carlton". med.nyu.edu. Retrieved 2018-03-25.
  9. ^ "The American Society of Parasitologists". Journal of Parasitology. 96 (6): 1048–1057. 2010-12-01. doi:10.1645/GE-2597.1. ISSN 0022-3395. S2CID 198156410.
  10. ^ "Stoll-Stunkard Memorial Lectureship". www.amsocparasit.org. Retrieved 2019-05-03.
  11. ^ "AAAS Members Elected as Fellows". AAAS - The World's Largest General Scientific Society. 2012-11-30. Retrieved 2018-03-25.
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