Juan Lerma Gómez

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Juan Lerma Gómez
Born (1955-06-08) June 8, 1955 (age 68)
NationalitySpanish
Academic work
DisciplineNeuroscience, physiology

Juan Lerma Gómez (born June 8, 1955) is a Spanish neuroscientist and research professor at the Instituto de Neurociencias in Alicante.[1] Currently he is editor-in-chief of Neuroscience, the official journal of the International Brain Research Organization, and scientific director of the programme "Severo Ochoa Center of Excellence" (2014-2022).

Biography[edit]

Lerma studied biology at the Complutense University of Madrid, and in 1979 started research at the Hospital Ramón y Cajal, under the mentorship of Elio Garcia-Austt, obtaining his PhD in sciences at the Autonomous University of Madrid in 1983. After six years as a faculty member at the hospital's Department of Research, he became a tenured staff researcher in the Instituto Cajal supported by the Consejo Superior de Investigaciones Científicas. In 1987, he moved to the Albert Einstein College of Medicine as a Fogarty Fellow, working with Mike V. L. Bennett and R. Suzanne Zukin. In 1990, he returned to Spain at the Instituto Cajal where he established his own lab. In 2000, he was promoted to full professor. In 2004, he moved to the Instituto de Neurociencias (Neurosciences Institute) in Alicante. He became vice-director (2005-2007) and director (2007-2016).[1]

Research[edit]

Lerma has focused his research on the molecular basis of neuronal communication, specifically on elucidating the properties and signaling mechanisms of glutamate receptors.

He described the existence of functional kainate receptors (KARs) in central neurons and applied single-cell RT-PCR to study neurotransmitter receptors.[2][3][4] He described the KAR's fundamental role in controlling neuronal tissue excitability and epileptogenesis, demonstrating that KARs have a dual mechanism of signaling.[5][6][7] He studied the role played by KARs at particular synapses and in the pathophysiology of brain diseases, in particular those related to mood disorders.[8][9]

Publications[edit]

Lerma has published over 100 papers in peer-reviewed scientific journals.[10]

Professional service[edit]

Honors and awards[edit]

  • Scientific Merit Award by Generalitat Valenciana (2013)
  • Maximum Distinction for Research Career by National University of San Marcos, Perú (2010)
  • Elected member of the Academia Europaea (2010)
  • XI "Alberto Sols" Award (Best Research Career) (2006)
  • Member of European Dana Alliance for the Brain (EDAB) (2005)
  • XVIII Award CEOE Foundation to Sciences (2004)
  • Alonso Gabriel de Herrera Excellence Award (2002)
  • Santiago Grisolía Award (2002)
  • Elected member of the European Molecular Biology Organization] (2000)
  • Distinction of the Health Sciences Foundation in Neurobiology (1998)

References[edit]

  1. ^ a b "Research Group webpage". in.umh-csic.es. Retrieved 2018-07-25.
  2. ^ Paternain, A. V; Morales, M; Lerma, J (1995). "Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons". Neuron. 14 (1): 185–189. doi:10.1016/0896-6273(95)90253-8. PMID 7826635. S2CID 6037517.
  3. ^ Lerma, J; V Paternain, A; Naranjo, J R; Mellström, B (1993). "Functional kainate-selective glutamate receptors in cultured hippocampal neurons". PNAS. 90 (24): 11688–11692. Bibcode:1993PNAS...9011688L. doi:10.1073/pnas.90.24.11688. PMC 48049. PMID 7505445.
  4. ^ Rodríguez-Moreno, A; Herreras, O; Lerma, J (1997). "Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus". Neuron. 19 (4): 893–901. doi:10.1016/S0896-6273(00)80970-8. PMID 9354335. S2CID 13561578.
  5. ^ Rodríguez-Moreno, A; Lerma, J (1998). "Kainate receptor modulation of GABA release involves a metabotropic function". Neuron. 20 (6): 1211–1218. doi:10.1016/S0896-6273(00)80501-2. PMID 9655508. S2CID 16739451.
  6. ^ Rozas, José Luis; Paternain, Ana V.; Lerma, Juan (2003-07-31). "Noncanonical signaling by ionotropic kainate receptors". Neuron. 39 (3): 543–553. doi:10.1016/S0896-6273(03)00436-7. PMID 12895426. S2CID 3208114.
  7. ^ Valbuena, Sergio; Lerma, Juan (2016-10-19). "Non-canonical signaling, the hidden life of ligand-gated ion channels". Neuron. 92 (2): 316–329. doi:10.1016/j.neuron.2016.10.016. hdl:10261/309684. PMID 27764665.
  8. ^ Aller, M. Isabel; Pecoraro, Valeria; Paternain, Ana V.; Canals, Santiago; Lerma, Juan (2015). "Increased dosage of high-affinity kainate receptor gene grik4 alters synaptic transmission and reproduces autism spectrum disorders features". Journal of Neuroscience. 35 (40): 13619–13628. doi:10.1523/JNEUROSCI.2217-15.2015. PMC 6605382. PMID 26446216.
  9. ^ Arora, Vineet; Pecoraro, Valeria; Aller, M. Isabel; Román, Celia; Paternain, Ana V.; Lerma, Juan (2018). "Increased Grik4 gene dosage causes imbalanced circuit output and human disease-related behaviors". Cell Reports. 23 (13): 3827–3838. doi:10.1016/j.celrep.2018.05.086. PMID 29949767.
  10. ^ "Juan Lerma". Google Scholar.

External links[edit]

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