Konstantinos Drosatos

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Konstantinos Drosatos
Born
Athens, Greece
NationalityGreek
CitizenshipGreek & USA
Education
Alma materAristotle University of Thessaloniki
Scientific career
Institutions
Thesis Gene regulation and functions of Apolipoprotein E  (2007)
Websitewww.drosatos.com

Konstantinos Drosatos (Greek: Κωνσταντίνος Δροσάτος), born in Athens, Greece, is a Greek-American molecular biologist, who is the Ohio Eminent Scholar and Professor of Pharmacology and Systems Physiology at the University of Cincinnati College of Medicine in Cincinnati, Ohio, U.S. His parents were Georgios Drosatos and Sofia Drosatou; his family originates in Partheni, Euboea, Greece.[1]

Education and career[edit]

Drosatos received his B.Sc. from the department of biology at the Aristotle University of Thessaloniki, Greece in 2000. In 2000, he continued with graduate studies at the Molecular Biology-Biomedicine graduate program of the department of biology and the medical school of the University of Crete. He received his M.Sc. in 2002 and his Ph.D. in molecular biology-biomedicine in 2007. During his graduate studies (2002–2007) he was a visiting research scholar in the laboratory of Vassilis I. Zannis[2] at Boston University Medical School. Following his graduation with a PhD in molecular biology-biomedicine in 2007, he joined the laboratory of Ira J. Goldberg at Columbia University, where he pursued post-doctoral training until 2012,[3] when he was promoted to associate research scientist in the department of medicine at Columbia University. In 2014 he joined the faculty of the Lewis Katz School of Medicine at Temple University as an assistant professor in pharmacology and in 2020, he was promoted to associate professor with tenure in cardiovascular sciences (primary affiliation). In 2022, he was recruited at the University of Cincinnati College of Medicine, which he joined as the Ohio Eminent Scholar and Professor of Pharmacology and Systems Physiology [4]

Research interests[edit]

The research in his laboratory focuses on cardiovascular and systemic metabolism and particularly on signaling mechanisms that link cardiac stress in diabetes, sepsis and ischemia with altered myocardial fatty acid metabolism. His published work focuses on the transcriptional regulation of proteins that underlie lipoprotein metabolism, cardiac and systemic fatty acid metabolism, and mitochondrial function. His work has identified the role of Krüppel-like factor 5 (KLF5) in the regulation of cardiac fatty acid metabolism in diabetes[5][6] and ischemic heart failure,[7] as well as how cardiac lipotoxicity leads to cardiac dysfunction,[8][9] and the importance of cardiac fatty acid oxidation and mitochondrial integrity for the treatment of cardiac dysfunction in sepsis.[10][11][12]

Distinctions and awards[edit]

  • 2014 Outstanding Early Career Award recipient, American Heart Association, BCVS Council[13]
  • 2016 Honorary Citizen, Eastern Mani Municipality, Greece
  • 2016 Visiting Professorship, UCLA Center for Systems Biomedicine
  • 2017 Early Research Investigator Award, Lewis Katz School of Medicine at Temple University
  • 2017 Elected Fellow (FAHA), American Heart Association
  • 2019 Elected Full Member, Sigma Xi, The Scientific Research Honor Society[14]
  • 2022 Visiting Professorship, School of Medicine, Aristotle University of Thessaloniki, Greece
  • 2022 Top-Reviewer 2022 for JACC: Basic to Translational Science[15]
  • 2023 Honorary Membership at the Biology Society of Cyprus[16]
  • 2023 Adjunct Professorship, European University of Cyprus[17]
  • 2023 Keynote Speaker, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland[18]
  • 2023 Keynote Speaker, Vascular and Heart Research Symposium, The Fralin Biomedical Research Institute, Virginia Tech at Roanoke[19]
  • 2024 Elected Fellow of the Graduate College of the University of Cincinnati[20]

Leadership positions[edit]

  • 2006–2010 – founding president of the board of directors, Hellenic Bioscientific Association of the USA[21]
  • 2012–2014 – president of the executive board, World Hellenic Biomedical Association[22]
  • 2019–2023 – vice-president of the executive council, ARISTEiA-Institute for the Advancement of Research & Education in Arts, Sciences & Technology[23]
  • 2020-2021 - Chair-elect of the Mid-career Committee, International Society for Heart Research-North American Section
  • 2023-2026 - General Secretary of the Executive Board, KOMVOS-NODE[24]
  • 2024-2028 - President of the executive council, ARISTEiA-Institute for the Advancement of Research & Education in Arts, Sciences & Technology[25]

References[edit]

  1. ^ "Partheni, Euboea, Greece".
  2. ^ "Laboratory of Vassilis I. Zannis".
  3. ^ "New and Competitively Renewed Peer-Reviewed Awards Received in 2012 (Columbia University, Department of Medicine)".
  4. ^ "University of Cincinnati College of Medicine - Profile of Konstantinos Drosatos".
  5. ^ Drosatos, Konstantinos (16 November 2015). "Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function". Circulation Research. 118 (2): 241–253. doi:10.1161/CIRCRESAHA.115.306383. PMC 4886555. PMID 26574507.
  6. ^ Kyriazis, Ioannis D.; Hoffman, Matthew; Gaignebet, Lea; Lucchese, Anna Maria; Markopoulou, Eftychia; Palioura, Dimitra; Wang, Chao; Bannister, Thomas D.; Christofidou-Solomidou, Melpo; Oka, Shin-Ichi; Sadoshima, Junichi; Koch, Walter J.; Goldberg, Ira J.; Yang, Vincent W.; Bialkowska, Agnieszka B.; Kararigas, Georgios; Drosatos, Konstantinos (2021). "KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy". Circulation Research. 128 (3): 335–357. doi:10.1161/CIRCRESAHA.120.316738. PMC 7870005. PMID 33539225.
  7. ^ Hoffman, Matthew; Palioura, Dimitra; Kyriazis, Ioannis D.; Cimini, Maria; Badolia, Rachit; Rajan, Sudarsan; Gao, Erhe; Nikolaidis, Nikolas; Schulze, P. Christian; Goldberg, Ira J.; Kishore, Raj; Yang, Vincent W.; Bannister, Thomas D.; Bialkowska, Agnieszka B.; Selzman, Craig H.; Drakos, Stavros G.; Drosatos, Konstantinos (March 16, 2021). "Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy". Circulation. 143 (11): 1139–1156. doi:10.1161/CIRCULATIONAHA.120.047420. ISSN 0009-7322. PMC 7965352. PMID 33430631.
  8. ^ Drosatos, Konstantinos; Bharadwaj, Kalyani G.; Lymperopoulos, Anastasios; Ikeda, Shota; Khan, Raffay; Hu, Yunying; Agarwal, Rajiv; Yu, Shuiqing; Jiang, Hongfeng; Steinberg, Susan F.; Blaner, William S.; Koch, Walter J.; Goldberg, Ira J. (2011). "Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation". American Journal of Physiology. Endocrinology and Metabolism. 300 (3): E489-99. doi:10.1152/ajpendo.00569.2010. PMC 3064003. PMID 21139071.
  9. ^ Bosma, Madeleen; Dapito, Dianne H.; Drosatos-Tampakaki, Zoi; Huiping-Son, Ni; Huang, Li-Shin; Kersten, Sander; Drosatos, Konstantinos; Goldberg, Ira J. (December 2014). "Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1841 (12): 1648–1655. doi:10.1016/j.bbalip.2014.09.012. PMC 4342292. PMID 25251292.
  10. ^ Drosatos, Konstantinos; Drosatos-Tampakaki, Zoi; Khan, Raffay; Homma, Shunichi; Schulze, P. Christian; Zannis, Vassilis I.; Goldberg, Ira J. (October 21, 2011). "Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction". Journal of Biological Chemistry. 286 (42): 36331–36339. doi:10.1074/jbc.M111.272146. PMC 3196095. PMID 21873422.
  11. ^ Drosatos, Konstantinos; Khan, Raffay S.; Trent, Chad M.; Jiang, Hongfeng; Son, Ni-Huiping; Blaner, William S.; Homma, Shunichi; Schulze, P. Christian; Goldberg, Ira J. (9 April 2013). "Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice". Circulation: Heart Failure. 6 (3): 550–562. doi:10.1161/CIRCHEARTFAILURE.112.000177. PMC 3690188. PMID 23572494.
  12. ^ Kokkinaki, Dimitra; Hoffman, Matthew; Kalliora, Charikleia; Kyriazis, Ioannis D.; Maning, Jennifer; Lucchese, Anna Maria; Shanmughapriya, Santhanam; Tomar, Dhanendra; Park, Joon Young; Wang, Hong; Yang, Xiao-Feng; Madesh, Muniswamy; Lymperopoulos, Anastasios; Koch, Walter J.; Christofidou-Solomidou, Melpo; Drosatos, Konstantinos (February 1, 2019). "Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy". Journal of Molecular and Cellular Cardiology. 127: 232–245. doi:10.1016/j.yjmcc.2018.12.016. PMC 6359996. PMID 30611795.
  13. ^ "Credentials, Lewis Katz School of Medicine at Temple University".
  14. ^ "Members Directory, Sigma Xi, The Scientific Research Honor society".
  15. ^ "JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude".
  16. ^ "Biology Society of Cyprus Honorary Member distinction".
  17. ^ "European University of Cyprus, Department of Health Sciences".
  18. ^ "TRINITY TRANSLATIONAL MEDICINE INSTITUTE CONFERENCE".
  19. ^ "2023 VASCULAR AND HEART RESEARCH SYMPOSIUM".
  20. ^ "Dr. Drosatos has been elected a Fellow of the University of Cincinnati Graduate College".
  21. ^ "Hellenic Bioscientific Association of the USA - Current and past leadership".
  22. ^ "World Hellenic Biomedical Association - Past Presidents".
  23. ^ "ARISTEiA - Executive Council Members".
  24. ^ "Τα μέλη του Διοικητικού Συμβουλίου της ΑΜΚΕ ε Κόμβος – ε Node: Δίκτυα του Παγκόσμιου Ελληνισμού".
  25. ^ "ARISTEiA - Executive Council Members".

External links[edit]

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