List of long term side effects of antipsychotics
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This is a general list of long-term side effects associated with Antipsychotic (neuroleptic) medication.
Many patients will not develop these side effects, although there is still a significant possibility of risks associated with Antipsychotic usage.
The percentage of patients affected by side effects like Tardive dyskinesia is significantly high and estimated to be a 20-50% prevalence.[1][2]
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development. Much is still being discovered about long term side- effects and insufficient research has been done to verify the mechanistic causes and severity of these long term side-effects[citation needed]
Overprescription of antipsychotics among seniors with dementia is evident[3][4][5][6][self-published source?] in spite of side effects.[citation needed]
List of potential long-term side effects[edit]
- Alzheimer's disease,[7][8]
- Akathisia
- Anhedonia
- Anxiety
- Cognitive dysfunction[9][10][11]
- Dementia worsening[12][13]
- Diabetes[14]
- Gynecomastia[15]
- Hyperglycemia
- hyperprolactinemia causes impotence in males.[16]
- Hyponatremia low sodium blood levels.
- Metabolic syndrome
- Neuroleptic-induced deficit syndrome
- Neuroleptic malignant syndrome
- Oculogyric crisis
- Parkinsonism
- Somnolence
- Tardive dyskinesia[17]
- Weight gain[18]
There has been a study that suggests antipsychotics are associated with possible cortical reconfiguration and gray matter loss, but correlational data also suggests patients who consume antipsychotics, like people with schizophrenia, tend to engage in unhealthy habits like smoking which may exacerbate gray matter loss.[19]
There are very few studies on healthy controls. There are also few studies of long term effects on animal controls. There are no studies on the long-term effects of polypharmacy (prescribing more than one anti-psychotic at a time), although the practice has been widespread.
See also[edit]
References[edit]
- ^ Martha Rosenberg (November 2019). "Drugmakers discover tardive dyskinesia. And they profit in it".
- ^ Waln, Olga; Jankovic, Joseph (12 July 2013). "An Update on Tardive Dyskinesia: From Phenomenology to Treatment". Tremor and Other Hyperkinetic Movements. 3: 03. doi:10.7916/D88P5Z71. PMC 3709416. PMID 23858394.
- ^ Gustafsson, Maria; Karlsson, Stig; Lövheim, Hugo (December 2013). "Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units". BMC Pharmacology and Toxicology. 14 (1): 10. doi:10.1186/2050-6511-14-10. PMC 3575309. PMID 23391323.
- ^ Jaffe, Ina (5 February 2018). "Risky Antipsychotic Drugs Still Overprescribed In Nursing Homes". NPR.
- ^ Spielmans, Glen I. (25 February 2015). "Atypical antipsychotics: overrated and overprescribed". The Pharmaceutical Journal.
- ^ "Antipsychotic overprescribing in people with learning disabilities". National Elf Service. 15 June 2016.
- ^ Yaffe, K.; Boustani, M. (9 September 2014). "Benzodiazepines and risk of Alzheimer's disease". BMJ. 349 (sep09 6): g5312. doi:10.1136/bmj.g5312. PMID 25205606. S2CID 206903228.
- ^ Sultzer, David L.; Davis, Sonia M.; Tariot, Pierre N.; Dagerman, Karen S.; Lebowitz, Barry D.; Lyketsos, Constantine G.; Rosenheck, Robert A.; Hsiao, John K.; Lieberman, Jeffrey A.; Schneider, Lon S. (July 2008). "Clinical Symptom Responses to Atypical Antipsychotic Medications in Alzheimer's Disease: Phase 1 Outcomes from the CATIE-AD Effectiveness Trial". The American Journal of Psychiatry. 165 (7): 844–854. doi:10.1176/appi.ajp.2008.07111779. PMC 2714365. PMID 18519523.
- ^ Rehse, Michael; Bartolovic, Marina; Baum, Katlehn; Richter, Dagmar; Weisbrod, Matthias; Roesch-Ely, Daniela (2016). "Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia". Schizophrenia Research and Treatment. 2016: 1–10. doi:10.1155/2016/8213165. PMC 4842070. PMID 27144021.
- ^ Tampi, Rajesh R.; Tampi, Deena J.; Balachandran, Silpa; Srinivasan, Shilpa (September 2016). "Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses". Therapeutic Advances in Chronic Disease. 7 (5): 229–245. doi:10.1177/2040622316658463. PMC 4994396. PMID 27583123.
- ^ MacKenzie, Nicole E.; Kowalchuk, Chantel; Agarwal, Sri Mahavir; Costa-Dookhan, Kenya A.; Caravaggio, Fernando; Gerretsen, Philip; Chintoh, Araba; Remington, Gary J.; Taylor, Valerie H.; Müeller, Daniel J.; Graff-Guerrero, Ariel; Hahn, Margaret K. (2018-12-05). "Antipsychotics, Metabolic Adverse Effects, and Cognitive Function in Schizophrenia". Frontiers in Psychiatry. 9: 622. doi:10.3389/fpsyt.2018.00622. PMC 6290646. PMID 30568606.
- ^ Mueller, Christoph; John, Christeena; Perera, Gayan; Aarsland, Dag; Ballard, Clive; Stewart, Robert (January 2021). "Antipsychotic use in dementia: the relationship between neuropsychiatric symptom profiles and adverse outcomes". European Journal of Epidemiology. 36 (1): 89–101. doi:10.1007/s10654-020-00643-2. PMC 7847435. PMID 32415541. S2CID 218652987.
- ^ Steinberg, Martin; Lyketsos, Constantine G. (September 2012). "Atypical Antipsychotic Use in Patients with Dementia: Managing Safety Concerns". The American Journal of Psychiatry. 169 (9): 900–906. doi:10.1176/appi.ajp.2012.12030342. PMC 3516138. PMID 22952071.
- ^ Holt, Richard I. G. (October 2019). "Association Between Antipsychotic Medication Use and Diabetes". Current Diabetes Reports. 19 (10): 96. doi:10.1007/s11892-019-1220-8. PMC 6718373. PMID 31478094.
- ^ Keskin, Necla; Tamam, Lut (2017-09-22). "Paliperidone-related gynecomastia and treatment: a case report". Dusunen Adam: The Journal of Psychiatry and Neurological Sciences: 258–261. doi:10.5350/DAJPN2017300310.
- ^ Tewksbury, Ashley; Olander, Amy (2016-07-01). "Management of antipsychotic-induced hyperprolactinemia". Mental Health Clinician. 6 (4): 185–190. doi:10.9740/mhc.2016.07.185. PMC 6007722. PMID 29955468.
- ^ Muller, Pavel; Seeman, Philip (1978). "Dopaminergic supersensitivity after neuroleptics: Time-course and specificity". Psychopharmacology. 60 (1): 1–11. doi:10.1007/BF00429171. PMID 32574. S2CID 22880818.
- ^ Dayabandara, Madhubhashinee; Hanwella, Raveen; Ratnatunga, Suhashini; Seneviratne, Sudarshi; Suraweera, Chathurie; de Silva, Varuni (August 2017). "Antipsychotic-associated weight gain: management strategies and impact on treatment adherence". Neuropsychiatric Disease and Treatment. 13: 2231–2241. doi:10.2147/NDT.S113099. PMC 5574691. PMID 28883731.
- ^ Ho, Beng-Choon; Andreasen, Nancy C.; Ziebell, Steven; Pierson, Ronald; Magnotta, Vincent (2011-02-07). "Long-term Antipsychotic Treatment and Brain Volumes: A Longitudinal Study of First-Episode Schizophrenia". Archives of General Psychiatry. 68 (2): 128–137. doi:10.1001/archgenpsychiatry.2010.199. PMC 3476840. PMID 21300943.