Margaret Tisdale
Margaret Tisdale (née Breeze; 10 September 1950[citation needed] – 29 April 2015) was a Welsh-born clinical virologist known for her studies of antiviral resistance in HIV and influenza virus, and for coordinating the development of the anti-influenza drug zanamivir.[1][2]
Biography[edit]
Born in Welshpool, Tisdale was educated at Trefnanney School and Welshpool Comprehensive, before attending Guildford University.[2]
Tisdale spent 33 years as a researcher at the Wellcome Research Laboratories, GlaxoWellcome and GlaxoSmithKline, where she eventually became head of clinical virology.[1][2] She was an expert in HIV drug resistance and in optimising antiretroviral therapy.[1] Tisdale headed the development of the influenza neuraminidase inhibitor zanamivir,[1] which Glaxo licensed from Biota in 1990. She established the global Neuraminidase Inhibitor Susceptibility Network in 1999 to track resistance to neuraminidase inhibitors in clinical strains of influenza virus.[1] She also published on antiviral drugs against rhinovirus, which causes the common cold.[3]
She died aged 64 in Wrestlingworth, Bedfordshire.[4]
Selected publications[edit]
- M Tisdale, SD Kemp, NR Parry, BA Larder (1993). Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America 90: 5653–56
- M Tisdale, T Alnadaf, D Cousens (1997). Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89. Antimicrobial Agents and Chemotherapy 41: 1094–98
- M Tisdale (2000). Monitoring of viral susceptibility: new challenges with the development of influenza NA inhibitors. Reviews in Medical Virology 10: 45–55
References[edit]
- ^ a b c d e "Gone in 2015: Commemorating 10 Outstanding Women in Science". Scientific American Blog Network. Retrieved 19 January 2016.
- ^ a b c "Tributes paid to Montgomeryshire scientist Margaret Tisdale who has died, aged 64". Denbighshire Free Press. 28 May 2015. Archived from the original on 26 January 2016. Retrieved 19 January 2016.
- ^ DJ Bauer; JWT Selway; JF Batchelor; M Tisdale; IC Caldwell; DAB Young (1981), "4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound", Nature, 292 (5821): 369–70, Bibcode:1981Natur.292..369B, doi:10.1038/292369a0, PMC 7094996, PMID 6265792
- ^ Sarah Knapton (27 January 2016), "Antidepressants can raise the risk of suicide, biggest ever review finds", The Daily Telegraph, retrieved 31 January 2016
- Welsh scholars and academics
- Welsh women scientists
- British virologists
- Women virologists
- HIV/AIDS researchers
- Influenza researchers
- 2015 deaths
- 1950 births
- 20th-century Welsh scientists
- 21st-century Welsh scientists
- People from Welshpool
- People from Wrestlingworth
- 20th-century Welsh women scientists
- 21st-century Welsh women scientists